Dengue hemorrhagic fever caused by sequential dengue 1-3 virus infections over a long time interval:: Havana epidemic, 2001-2002
Dengue hemorrhagic fever caused by sequential dengue 1-3 virus infections over a long time interval:: Havana epidemic, 2001-2002
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DOI：
10.4269/ajtmh.2006.75.1113
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发表时间：
2006-12-01
影响因子：
3.3
通讯作者：
Guzman, Maria G.
中科院分区：
文献类型：
--
作者：
Alvarez, Mayling;Rodriguez-Roche, Rosmari;Guzman, Maria G.
2001-2002年，古巴发生了由登革热病毒3型（DENV-3）引起的登革热流行。其中包括登革出血热/登革休克综合征病例。我们报告了对78名DHF/DSS患者中的54名患者血清的中和抗体研究，这些患者提供了DENV-1随后DENV-3发生感染的证据。没有血清显示DENV-2后接DENY-3序列的感染。一些血清显示出DENV-1，随后是DENV-2，然后是DENV-3的感染模式。然而，三级感染的明确分类是不可能的，因为广泛反应性抗体，其可能是由DENV-1然后DENV-3的感染引起的。
A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We report neutralizing antibody studies on sera from 54 of 78 DHF/DSS patients that provide evidence of infections occurring in the sequence DENV-1 followed by DENV-3. No sera showed infection in the sequence DENV-2 followed by DENY-3. Some sera showed a pattern of infection in the sequence DENV-1 followed by DENV-2 and then DENV-3. However definitive categorization of a tertiary infection was not possible because of broadly reactive antibodies, which could have been raised by infections in the sequence DENV-1 then DENV-3.