Association between bovine casein antibody and new onset schizophrenia among US military personnel
Association between bovine casein antibody and new onset schizophrenia among US military personnel
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DOI：
10.1016/j.schres.2011.02.005
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发表时间：
2011-05-01
影响因子：
4.5
通讯作者：
Yolken, Robert
中科院分区：
文献类型：
--
作者：
Niebuhr, David W.;Li, Yuanzhang;Yolken, Robert
精神分裂症是一种病因不明的普遍神经精神障碍。多项研究已经证明精神分裂症患者的免疫激活。一种能够诱导持久免疫反应的抗原是从摄入的奶制品中提取的牛酪蛋白。确诊后，精神分裂症患者体内的酪蛋白抗体水平升高。这项研究旨在确定精神分裂症与发病前牛酪蛋白免疫球蛋白G抗体水平之间的潜在联系。同时对双相情感障碍患者的酪蛋白抗体水平进行平行分析，作为对比。病例是1992至2005年间因精神分裂症诊断而从军队退役的军人。选择855例患者和1165例健康体检者的血清标本。采用固相酶联免疫吸附试验(ELISAs)检测牛全酪蛋白抗体。计算危险比(HR)，以检验酪蛋白免疫球蛋白水平与精神分裂症发病风险之间的关系。诊断前抽取的酪蛋白抗体水平越高，单位抗体水平(低阳性标准值)增加的精神分裂症危险风险增加18%(HR=1.18；95%可信区间1.04，1.34)。这是第一份确定精神分裂症风险与发病前牛酪蛋白抗体升高之间关系的报告。还需要更多的研究来阐明精神分裂症发病机制中涉及的复杂遗传环境相互作用，并确定潜在的可改变的危险因素。爱思唯尔出版公司(Elsevier B.V.)
Schizophrenia is a pervasive neuropsychiatric disorder of uncertain etiology. Multiple studies have documented immune activation in individuals with schizophrenia. One antigen capable of inducing a prolonged immune response is bovine casein derived from ingested milk products. Increased levels of casein antibodies have been found in individuals with schizophrenia after diagnosis. This study was directed at determining the potential association between schizophrenia and pre-illness onset levels of immunoglobulin G (IgG) antibodies to bovine casein. Parallel analyses for casein antibody levels with bipolar disorder were included as comparison. Cases were service members who received medical discharges from the military with a schizophrenia diagnosis from 1992 to 2005. Serum specimens were selected for 855 cases and 1165 matched healthy controls. IgG antibodies to bovine whole-casein were measured by solid phase enzyme-linked immunosorbent assays (ELISAs). Hazard ratios (HR) were calculated to examine the associations of casein IgG level with risk of schizophrenia by time to diagnosis and by subjects' initial level. Increasing casein IgG antibody levels among those with a high initial level, drawn before diagnosis, was associated with an 18% increase in the hazard risk of schizophrenia per unit increase (value of low-positive standard) in IgG antibody levels (HR = 1.18; 95% CI 1.04, 1.34). This is the first report to identify an association between the risk of schizophrenia and elevated antibodies to bovine casein prior to disease onset. Additional research is required to elucidate the complex genetic environmental interactions involved in the pathogenesis of schizophrenia and to identify potentially modifiable risk factors. Published by Elsevier B.V.