Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection
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DOI：
10.5761/atcs.oa.18-00187
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发表时间：
2019-01-01
影响因子：
1.3
通讯作者：
Jin, Mu
中科院分区：
文献类型：
--
作者：
Li, Shuwen;Lu, Jiakai;Jin, Mu
目的：血小板是凝血过程中的重要组成部分，低入院时的血小板计数(PLC)与斯坦福A型急性主动脉夹层(AAD)患者的不良临床结局有关。收集患者的术前临床和实验室数据。结果：调整多元回归分析显示，年龄(β：-1.069，95%可信区间[CI]：-2.109，-0.029)、性别(β：-29.973，95%可信区间：-56.512，-3.433)、组织因子途径抑制物(TFP I；BETA：0.197，95%CI：0.039，0.354)、纤维蛋白原降解产物(BETA：-0.476，95%CI：-0.879，-0.074)、发病时间(BETA：11.125，95%CI：7.963，14.287)与入院PLC显著相关。入院PLC随发病时间的延长而增加(Beta：16.2，95%CI：12.1，20.2)。结论：入院PLC与年龄增大、男性、血清TFPI水平低、FDP水平高、发作时间短的患者显著相关。此外，发病转折点为夹层开始后3天。
Purpose: Platelets are crucial components of the coagulation processes, and low admission platelet count (PLC) is associated with adverse clinical outcomes in patients with Stanford type A acute aortic dissection (AAD).Methods: A total of 130 consecutive patients undergoing Stanford type A AAD surgery in Beijing Anzhen Hospital were enrolled between January 2013 and July 2014. Preoperative clinical and laboratory data from patients were collected. Multiple regression analyses were used to determine the independent factors of low admission platelets.Results: Adjusted multiple regression analysis showed that age (beta: -1.069, 95% confidence interval [CI]: -2.109, -0.029), sex (beta: -29.973, 95% CI: -56.512, -3.433), tissue factor pathway inhibitor (TFPI; beta: 0.197, 95% CI: 0.039, 0.354), fibrinogen degradation product (FDP) (beta: -0.476, 95% CI: -0.879, -0.074), and attack time (beta: 11.125, 95% CI: 7.963, 14.287) were significantly associated with admission PLC. Admission PLC increased with attack time up to the 3 days (beta: 16.2, 95% CI: 12.1, 20.2).Conclusions: We found that increasing age, male patients, patients with lower serum levels of TFPI and higher serum levels of FDP, and patients with a shorter attack time were significantly associated with lower PLC at admission. Moreover, the turning point of attack time is 3 days after the onset of dissection.