Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery
Nanodiamond Vectors Functionalized with Polyethylenimine for siRNA Delivery
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DOI：
10.1021/jz1013278
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发表时间：
2010-11-04
影响因子：
5.7
通讯作者：
Ho, Dean
中科院分区：
文献类型：
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作者：
Chen, Mark;Zhang, Xue-Qing;Ho, Dean
RNA 干扰 (RNAi) 的巨大治疗潜力早已得到认可。虽然存在有效的小干扰 RNA (SiRNA) 递送载体，但许多载体牺牲了生物相容性，这可能会挑战它们作为治疗剂的适用性。纳米金刚石 (ND) 代表了高效 siRNA 递送的有前途的策略，因为它具有集成到一个平台中的多种有益特性，包括均匀的粒径材料可扩展性、携带几乎任何类型治疗剂的能力以及保留的生物相容性等。在这里，我们提出了一个广泛适用的 ND 递送平台，该平台证明了生物相容性 siRNA 递送在介质中具有增强的功效，这表明了该方法的转化潜力。
The enormous therapeutic potential of RNA interference (RNAi) has long been recognized. While efficient small interfering RNA (SiRNA) delivery vectors exist, many sacrifice biocompatibility, which can challenge their applicability as a therapeutic agent. Nanodiamonds (NDs) represent promising strategies for efficient siRNA delivery given the multitude of beneficial properties integrated into one platform that include uniform particle sizes material scalability, the ability to carry nearly any type of therapeutic, and preserved biocompatibility, among others. Here we present a broadly applicable ND delivery platform that demonstrates biocompatible siRNA delivery with enhanced efficacy in media, signifying the translational potential of this approach.