Relapse to cocaine abuse after initiating desipramine treatment.
Relapse to cocaine abuse after initiating desipramine treatment.
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开始地昔帕明治疗后，可卡因滥用复发。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Weiss
中科院分区：
文献类型：
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作者：
R. Weiss
三个可卡因滥用者谁已经戒断了一至六个月后，重新开始使用可卡因盐酸地昔帕明治疗后不久。在每种情况下，抗抑郁药治疗开始的原因不同。这三名患者都出现了所谓的早期三环神经过敏综合征。这种反应可能刺激了对可卡因的条件性渴望，因为这种综合征与可卡因中毒之间的相似性。由于地昔帕明被用来减少可卡因的渴望，重要的是要认识到这种矛盾的增加渴望作为一个潜在的不利影响地昔帕明。
Three cocaine abusers who had been abstinent for one to six months relapsed to cocaine use soon after beginning desipramine hydrochloride therapy. The antidepressant treatment was begun for different reasons in each case. All three patients developed what has been termed the early tricyclic jitteriness syndrome. This reaction may have stimulated conditioned craving for cocaine because of the similarity between this syndrome and cocaine intoxication. Since desipramine is being used to reduce cocaine craving, it is important to recognize this paradoxical increase in craving as a potential adverse effect of desipramine.