A novel cell therapy for stress urinary incontinence, short-term outcome
A novel cell therapy for stress urinary incontinence, short-term outcome
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DOI：
10.1002/nau.22301
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发表时间：
2013-04-01
影响因子：
2
通讯作者：
Seifalian, Alexander M.
中科院分区：
文献类型：
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作者：
Shirvan, Maliheh Keshvari;Alamdari, Daryoush Hamidi;Seifalian, Alexander M.
目的本研究的目的是评估尿道注射自体总有核细胞（TNCs）沿着血小板的安全性，其重点是6个月期间的结果。方法对9例重度压力性尿失禁（SUI）患者进行开放性、前瞻性研究。在基线时，在尿道外括约肌和粘膜下注射自体TNCs沿着血小板后1、3和6个月，根据咳嗽试验、Q-Tip试验、尿动力学、1小时尿垫试验、上尿路超声检查（UTU）、排尿后残留物（PVR）、国际尿失禁咨询（ICIQ-UI）、国际营养模块化评估-生活质量咨询（ICIQ-QOL）。在注射后3个月，对1例内源性括约肌功能不全（ISD）患者的最大尿道闭合压（MUCP）和腹漏点压（ALPP）进行了测量;基线：ALPP
Aims The aim of this study was the safety assessment of urethra injections of autologous total nucleated cells (TNCs) along with platelets, which focused on the outcome over a 6 month period. Methods An open, prospective study was conducted on 9 patients with severe stress urinary incontinence (SUI). At the baseline, 1, 3, and 6 months after external urethral sphincteric and submucosal injections of autologous TNCs along with platelets, the patients were assessed according to cough tests, Q-Tip tests, urodynamics, 1hr pad tests, upper tract ultrasonography (UTU), post voiding residue (PVR), International Consultation on Incontinence Questionnaire-Urinary incontinence (ICIQ-UI), and International Consultation on Incontinence Modular Questionnaire-Quality of Life (ICIQ-QOL). On the 3rd month post-injection, the maximum urethral closure pressure (MUCP) and abdominal leak point pressure (ALPP) were measured in one patient with intrinsic sphincteric deficiency (ISD; the baseline: ALPP