Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients
Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients
复制标题
DOI：
10.1093/ndt/gfh052
复制
发表时间：
2004-05-01
影响因子：
6.1
通讯作者：
Tetta, C
中科院分区：
文献类型：
--
作者：
Panichi, V;Maggiore, U;Tetta, C
背景。尽管白细胞介素 6 (IL-6) 与心血管死亡率之间的关联众所周知，但迄今为止还没有研究证实 IL-6 是否可以为 C 反应蛋白 (CRP) 提供的预后信息增加预后信息。方法。对来自四个不同透析中心的 218 名血液透析患者进行了回顾性随访。测定血浆IL-6和CRP浓度。可获得 162 名患者的合并症的完整信息。结果。就最低四分位数（CRP 为 12.8 mg/l）而言，IL-6 为 5.20（95% 置信区间 2.06-13.011），CRP 为 3.16（1.41-7.12）。当包括两个变量时，IL-6 的估计值为 4.10 (1.30-12.96)，CRP 的估计值为 1.29 (0.47-3.57)。对于连续变量，两个变量与死亡率之间的关系在最高值时趋于平稳，但在变量对数变换后变得相当线性。对于 1 个单位 SD 的对数（变量），IL-6 的 RR 为 2.09 (1.52-2.88)，CRP 的 RR 为 1.66 (1.23-2.24)。当它们包含在同一模型中时，IL-6 的估计值为 1.90 (1.18-2.82)，CRP 的估计值为 1.16 (0.81-1.66)。结论。 IL-6 对心血管死亡率的预测价值比 CRP 更强，并提供独立的预后信息，同时传达了 CRP 提供的大部分信息。
Background. Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP).Methods. A cohort of 218 haemodialysis patients from four different dialytic centres was followed-up retrospectively. Plasma IL-6 and CRP concentrations were determined. Full information on co-morbidities was available in 162 patients.Results. With respect to the lowest quartile (12.8 mg/l for CRP) was 5.20 (95% confidence interval 2.06-13.011) for IL-6 and 3.16 (1.41-7.12) for CRP. When both variables were included, the estimates were 4.10 (1.30-12.96) for IL-6 and 1.29 (0.47-3.57) for CRP. As to continuous variables, the relationship between both variables and mortality tended to level off for the highest values, but became fairly linear after log transformation of the variables. For one unit SD of the log (variable), the RR was 2.09 (1.52-2.88) for IL-6 and 1.66 (1.23-2.24) for CRP. When they were included in the same model, the estimates were 1.90 (1.18-2.82) for IL-6 and 1.16 (0.81-1.66) for CRP.Conclusions. IL-6 has a stronger predictive value than CRP for cardiovascular mortality and provides independent prognostic information, while conveying most of that provided by CRP.