Immortalizing the complexity of cancer metastasis - Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
Immortalizing the complexity of cancer metastasis - Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
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DOI：
10.4161/cbt.4.5.1663
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发表时间：
2005-05-01
影响因子：
3.6
通讯作者：
Iacobuzio-Donahue, CA
中科院分区：
文献类型：
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作者：
Embuscado, EE;Laheru, D;Iacobuzio-Donahue, CA
事实上，缺乏良好表征的转移性胰腺癌组织用于研究，限制了对这种致命疾病的转移过程的系统研究。为了解决这一重要问题，我们制定了一项快速尸检方案，用于从转移性胰腺癌患者中收集高质量组织，称为胃肠癌快速医疗捐赠计划（GICRMDP）。在撰写本手稿时，20例转移性胰腺癌患者和1例转移性结肠癌患者接受了与GICRMDP相关的快速尸检。这21名患者达到的平均时间间隔为8.0小时，迄今为止获得了超过500个匹配的高质量原发性和转移性胰腺癌组织、腹膜/胸膜液和血液的个体样品。对于在2009年进行尸检的前四名患者，
The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important issue, we have instituted a rapid autopsy protocol for the collection of high quality tissues from patients with metastatic pancreatic cancer, called the Gastrointestinal Cancer Rapid Medical Donation Program (GICRMDP). At the time of preparation of this manuscript, 20 patients with metastatic pancreatic cancer and one patient with metastatic colon cancer have undergone a rapid autopsy in association with the GICRMDP. The average time interval achieved for these 2 1 patients was 8.0 hours, with more than 500 individual samples of matched high quality primary and metastatic pancreatic cancer tissues, peritoneal/pleural fluid and blood obtained so far. For the first four patients in which the autopsy was performed in