Normal and abnormal development of human embryos: first report of the analysis of 1,213 intact embryos.
Normal and abnormal development of human embryos: first report of the analysis of 1,213 intact embryos.
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人类胚胎的正常和异常发育：第一份对 1,213 个完整胚胎进行分析的报告。
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
Mineo Yasuda
中科院分区：
文献类型：
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作者：
Hideo Nishimura;Kiichi Takano;Takashi Tanimura;Mineo Yasuda
通过对大量来自健康女性的人类胚胎发育的研究，我们在头臀长、体重和外形方面建立了比通常引用的标准更可靠的正常发育标准。在临床年龄和这些属性之间的关系方面注意到显着的变化，因此可以得出结论，顶臀长和体重是比临床确定的年龄更可靠的一般发育状态指标。
有妊娠期生殖器出血史的妇女死亡胚胎的发生率明显高于无生殖器出血史的妇女。随着发育阶段的推进，外部畸形胚的出现频率逐渐增加，在层位19-23时，外部畸形胚的出现频率最高，为3.92%。观察到的畸形包括外部缺陷，如露脑畸形、独眼畸形、脊髓劈裂、唇裂和几种肢体畸形。值得注意的是，大多数这些缺陷的发生率远远高于新生儿。
This survey of the development of a large number of virtually unselected human embryos from healthy women allowed us to establish more reliable standards of normal development with respect to crown-rump length, body weight, and external form than those usually cited. Remarkable variation was noted with regard to the relation between clinical age and these attributes and thus it is concluded that crown-rump length and body weight are more reliable indicators of the general state of development than clinically established age.
Dead embryos occurred with a significantly greater frequency in women with a history of genital bleeding during pregnancy than in those without. Externally malformed embryos were found with increasing frequency with advancing developmental stage, with the maximum figure of 3.92% at horizons 19–23. Malformations observed included external defects such as exencephaly, cyclopia, myeloschisis, cleft lip, and several limb malformations. It is of considerable interest that the incidence of most of these defects was far higher than that observed in newborn infants.