Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer.
Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer.
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DOI：
10.3233/blc-170129
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发表时间：
2018-01-20
期刊：
影响因子：
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通讯作者：
Plimack ER
中科院分区：
文献类型：
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作者：
Abbosh PH;Plimack ER
DNA损伤反应与修复基因（DDR基因）在膀胱癌中普遍发生突变。这些突变的生物学影响是一个具有强烈基础、转化和临床兴趣的领域。随着下一代测序技术在局部和晚期膀胱癌治疗中的立足点越来越大，DDR基因的作用将继续演变。我们回顾了膀胱癌中DDR基因的清单和生物学，并描述了DDR基因缺失导致对各种抗癌药物的治疗敏感性的已知和候选作用。
DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents.