A longitudinal brain MRI study comparing the sensitivities of the conventional and a newer approach for detecting active lesions in multiple sclerosis
A longitudinal brain MRI study comparing the sensitivities of the conventional and a newer approach for detecting active lesions in multiple sclerosis
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DOI：
10.1016/s0022-510x(98)00144-0
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发表时间：
1998-07-15
影响因子：
4.4
通讯作者：
Comi, G
中科院分区：
文献类型：
--
作者：
Filippi, M;Mastronardo, G;Comi, G
每月双回波自旋回波（SE）和增强磁共振成像（MRI）后，注射标准剂量（SD）的钆（Gd）是监测短期疾病活动的多发性硬化症（MS）的常规方法。在这项研究中，将这种方法检测MS活动性病变的灵敏度与注射三倍剂量（TD）Gd后每月快速液体衰减反转恢复（FLAIR）扫描与增强MRI相关的灵敏度进行了比较。13例复发缓解型MS患者进入研究。每月MRI扫描获得了四个场合在两个单独的会话（间隔12和24小时）。在一个会话中，获得双回波常规SE和SD T1加权扫描;在另一个会话中，快速FLAIR和TD T1加权扫描。两次治疗的顺序是随机的。由三名观察员对两种方法检测到的活动性病变数量进行计数。传统方法检测到104处活动性病变，新方法检测到199处活动性病变（每例患者平均增加= 75%，范围=0-325%）。每例患者每月活动性病变的平均数量为2.0例传统入路和3.8例新入路（P=0.004）。常规入路和新入路的活动性病变扫描分别为34/52（65%）和37/52（71%）。我们的数据表明，每月快速FLAIR和TD增强T1加权扫描的联合使用增加了MS患者连续MRT扫描检测到的活动性病变数量。（C）1998 Elsevier Science B. V.版权所有。
Monthly dual-echo spin-echo (SE) and enhanced magnetic resonance imaging (MRI) after the injection of a standard dose (SD) of gadolinium (Gd) is the conventional approach to monitor short-term disease activity in multiple sclerosis (MS). In this study, the sensitivity of this approach in detecting active lesions in MS was compared with that of monthly fast fluid attenuated inversion recovery (FLAIR) scans associated with enhanced MRI after the injection of a triple dose (TD) of Gd. Thirteen patients with relapsing-remitting MS entered the study. Monthly MRI scans were obtained on four occasions in two separate sessions (interval between 12 and 24 h). In one session, dual-echo conventional SE and SD T1-weighted scans were obtained; in the other, fast-FLAIR and TD T1-weighted scans. The order of the two sessions was randomized. Three observers counted the numbers of active lesions detected by each of the two approaches. One hundred and four active lesions were detected by the conventional approach and 199 by the newer approach (average increase per patient=75%, range=0-325%). The mean number of active lesions per month per patient was 2.0 for the conventional approach and 3.8 for the new approach (P=0.004). Scans with active lesions were 34/52 (65%) with the conventional approach and 37/52 (71%) with the new approach. Our data indicate that the combined use of monthly fast-FLAIR and TD enhanced T1-weighted scans increases the number of active lesions detected on serial MRT scans from patients with MS. (C) 1998 Elsevier Science B.V. All rights reserved.