Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study
Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study
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DOI：
10.1016/s0896-6273(00)80657-1
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发表时间：
1998-12-01
期刊：
影响因子：
16.2
通讯作者：
Sharp, PE
中科院分区：
文献类型：
--
作者：
Blair, HT;Cho, JW;Sharp, PE
我们记录了自由活动大鼠侧乳核（LMN）和丘脑前部（ATN）的头部方向（HD）细胞，并在记录ATN HD细胞的同时制作了双侧LMN病变。我们发现，与头部不转动时相比，LMN HD细胞的调谐功能在有争议的头部转动时变窄，而在有争议的头部转动时没有变窄。这种缩窄效应不会发生在ATN HD细胞中。我们还发现，LMN中的HD信号比ATN中的HD信号超前约15-20 ms。当LMN双侧受损时，ATN中的HD细胞立即失去定向发射特性，且无法恢复。基于这些发现，我们认为LMN可能是参与产生HD信号的吸引-积分器网络的重要组成部分。
We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowing effect does not occur for ATN HD cells. We also found that the HD signal in LMN leads that in ATN by about 15-20 ms. When LMN was lesioned bilaterally, HD cells in ATN immediately lost their directional firing properties and never recovered them. Based on these findings, we argue that LMN may be an essential component of an attractor-integrator network that participates in generating the HD signal.