Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis.
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis.
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DOI：
10.1155/2016/3543678
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发表时间：
2016
影响因子：
4.3
通讯作者：
Tripodi M
中科院分区：
文献类型：
--
作者：
Strippoli R;Moreno-Vicente R;Battistelli C;Cicchini C;Noce V;Amicone L;Marchetti A;Del Pozo MA;Tripodi M
腹膜透析是替代血液透析的一种肾脏替代疗法。在这种治疗过程中，腹膜起到了溶质和水交换的渗透屏障的作用。持续暴露于透析液，以及腹膜炎和腹膜积血，可导致急性/慢性炎症和腹膜损伤，继而发生进行性纤维化、血管生成和血管病变，最终导致腹膜透析中断。在控制这一病理过程的不同事件中，间皮细胞上皮细胞向间充质细胞的转变在腹膜纤维化的诱导和随后的腹膜功能恶化中起主要作用。在这里，主要的胞外诱导物和细胞球员被描述。此外，还阐明了在这一过程中发挥作用的信号通路，重点阐述了转化生长因子-β家族成员和Toll样/IL-1β受体传递的信号。了解腹膜纤维化的分子机制既有基础意义，也有翻译意义，因为它可能有助于建立旨在对抗腹膜恶化和恢复腹膜内稳态的治疗方法。
Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.