Mechanical properties of cross-linked synthetic elastomeric polypentapeptides
Mechanical properties of cross-linked synthetic elastomeric polypentapeptides
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DOI：
10.1021/ma0017844
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发表时间：
2001-08-14
期刊：
影响因子：
5.5
通讯作者：
Urry, DW
中科院分区：
文献类型：
--
作者：
Lee, J;Macosko, CW;Urry, DW
检测了两种弹性聚五肽，即（GVGVP）（251）和（GVGIP）（260）在平衡溶胀状态下的机械性能，其中G =甘氨酸，V =缬氨酸，P =脯氨酸，I =异亮氨酸。它们是使用重组DNA技术制备的，并通过6至30 Mrad剂量范围内的γ辐照交联。在单轴拉伸试验中测量模量。确定断裂比功作为韧性的量度。增加剂量的γ-辐射增加了水凝胶的模量（交联密度）。温度升高时发生的疏水折叠和组装相变被证明对模量和断裂性能有显着影响。热弹性实验表明，相变涉及弹性机制的变化。在转变温度以上，水凝胶显示出变得更加粘弹性。
Mechanical properties in equilibrium swelling states were examined for two elastomeric polypentapeptides, namely, (GVGVP)(251) and (GVGIP)(260) where G = glycine, V = valine, P = proline, and I = isoleucine. They had been prepared using recombinant DNA technology and cross-linked by gamma -irradiation over the range of doses from 6 to 30 Mrad. Moduli were measured in uniaxial tensile tests. The specific work of fracture was determined as a measure of toughness. Increased doses of gamma -radiation increased the moduli (cross-link density) of hydrogels. The hydrophobic folding and assembly phase transition that occurred on raising the temperature was demonstrated to have significant effects on moduli and fracture properties. Thermoelasticity experiments suggest that the phase transition involves changes in elasticity mechanism. Above the transition temperature, hydrogels were shown to become more viscoelastic.