Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones.
Evidence for involvement of guanine nucleotide-binding regulatory proteins in the activation of phospholipases by hormones.
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鸟嘌呤核苷酸结合调节蛋白参与激素激活磷脂酶的证据。
DOI：
10.1096/fasebj.2.10.2838362
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Wojcikiewicz,RJ
中科院分区：
文献类型：
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作者：
Fain,JN;Wallace,MA;Wojcikiewicz,RJ
鸟嘌呤核苷酸结合调节蛋白类似于g和gimi可能参与磷脂酶C和a2被激素和其他配体激活。鸟嘌呤核苷酸减少了激素与激活磷脂酶C受体的结合，这些激素也刺激细胞膜中高亲和力的GTPase活性。在无细胞制剂中，激素对磷脂酶C活性的影响取决于鸟嘌呤核苷酸的存在。此外，氟化物和不可水解的GTP类似物以一种可以被GDPβS阻断的方式激活磷脂酶。可能参与磷脂酶C活化的鸟嘌呤核苷酸结合调节蛋白在某些细胞中对百日咳毒素敏感，但在其他细胞中不敏感。-费恩，j.n.；华莱士，文学硕士；鸟嘌呤核苷酸结合调节蛋白参与激素激活磷脂酶的证据。中国生物医学工程学报，21(2):569‐574；1988.
Guanine nudeotide‐binding regulatory proteins similar to Gsand Gimay be involved in the activation of phospholipases C and A2by hormones and other ligands. The binding of hormones to receptors that activate phospholipase C is decreased by guanine nucleotides and these hormones also stimulate a high‐affinity GTPase activity in cell membranes. Effects of hormones on phospholipase C activity in cell‐free preparations are dependent on the presence of guanine nucleotides. In addition, fluoride and nonhydrolyzable GTP analogs activate phospholipases in a manner that can be blocked by GDPβS. The putative guanine nucleotide‐binding regulatory protein that appears to be involved in activation of phospholipase C is sensitive to pertussis toxin in some cells but not in others.— Fain, J. N.; Wallace, M. A.; Wojcikiewigz, R. J. H. Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones.FASEB J, 2: 2569‐2574; 1988.