High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: A cross-sectional study
High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: A cross-sectional study
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DOI：
10.1016/j.atherosclerosis.2015.01.011
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发表时间：
2015-03-01
期刊：
影响因子：
5.3
通讯作者：
Tatsuno, Ichiro
中科院分区：
文献类型：
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作者：
Nagayama, Daiji;Yamaguchi, Takashi;Tatsuno, Ichiro
目的：研究血尿酸（SUA）与心踝血管指数（CAVI）评估的动脉僵硬度之间的关系。方法：我们分析了27,360名日本健康受试者（12,910名男性和14,450名女性）的横断面数据，年龄在20 - 74岁之间，既往无心脏病、中风、高血压、糖尿病、肾炎或痛风。结果：男性BMI、CAVI、收缩压/舒张压、GOT、GPT、γ-GTP、甘油三酯（TG）、肌酐、SUA均高于女性，HDL-C低于女性。然后，将他们按SUA分为3组：下三分位数（T1）、中三分位数（T2）和上三分位数（T3），并按性别分层。在对CAVI进行多元回归分析中确定的年龄、BMI和收缩压（sBP）进行调整后，CAVI随SUA三分位数的增加而进行性增加。多因素分析显示，相对于T1，高CAVI的优势比（95%CI）（>第90百分位数）为1.233调整混杂因素后，男性T2和T3分别为（0.928-1.638）和1.352（1.031-1.773），女性T2和T3分别为1.133（0.984-1.303）和1.361（1.098-1.687）。此外，增加调整后的CAVI中观察到在一个较低的SUA范围内的女性相比，观察到在males.Conclusion：我们证明了一个独立的相关性之间的SUA和CAVI，并观察性别差异的SUA范围内增加CAVI。这些结果可能表明，在预防动脉粥样硬化的抗高尿酸血症治疗中，需要为男性和女性设定不同的目标SUA水平。(C)2015爱思唯尔爱尔兰有限公司版权所有。
Objective: To investigate the association of serum uric acid (SUA) with arterial stiffness assessed by cardio-ankle vascular index (CAVI).Methods: We analyzed the cross-sectional data from 27,360 healthy Japanese subjects (12,910 males and 14,450 females) aged between 20 and 74 years without a past history of heart disease, stroke, hypertension, diabetes, nephritis or gout. We investigated whether SUA was independently associated with CAVI in a gender-specific manner.Results: BMI, CAVI, systolic/diastolic BP, GOT, GPT, gamma-GTP, triglyceride (TG), creatinine and SUA were higher and HDL-C was lower in males than in females. Next, they were stratified by SUA into 3 groups: lower tertile (T1), middle tertile (T2) and upper tertile (T3) and by gender. CAVI increased progressive with increasing SUA tertile, after adjusting for age, BMI and systolic BP (sBP) identified in multiple regression analysis for CAVI. Multivariate analysis showed that the odds ratios (95% CI) relative to T1 for high CAVI (> 90th percentile) were 1.233 (0.928-1.638) in T2 and 1.352 (1.031-1.773) in T3 for males, and 1.133 (0.984-1.303) in T2 and 1.361 (1.098-1.687) in T3 for females, after adjusting for confounders. Furthermore, increase in adjusted CAVI was observed in a lower SUA range in females compared to that observed in males.Conclusion: We demonstrated an independent correlation between SUA and CAVI, and observed gender difference in the SUA range for increase in CAVI. These results may suggest the need to set different target SUA levels for men and women in anti-hyperuricemic treatment for atherosclerosis prevention. (C) 2015 Elsevier Ireland Ltd. All rights reserved.