Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai
Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai
复制标题
上海市2000-2009年幽门螺杆菌对抗生素的耐药情况
DOI：
10.3748/wjg.v16.i40.5118
复制
发表时间：
2010-10-28
影响因子：
4.3
通讯作者：
Lu, Hong
中科院分区：
文献类型：
--
作者：
Sun, Qin-Juan;Liang, Xiao;Lu, Hong
目的：了解幽门螺杆菌（H. pylon）对6种常用抗生素的敏感性。采用琼脂稀释法检测2000 ~ 2009年上海地区幽门螺杆菌对甲硝唑、克拉霉素、阿莫西林、呋喃唑酮、左氧氟沙星和四环素的敏感性。克拉霉素（8.6%）、左氧氟沙星（10.3%）、克拉霉素（9.0%）、左氧氟沙星（24.0%）、左氧氟沙星（32.5%）的耐药率呈上升趋势。H. pylori对甲硝唑的敏感性保持稳定（40%-50%）。只有一株H. 2005年分离出的幽门螺杆菌对四环素耐药。所有菌株均对阿莫西林和呋喃唑酮敏感。H. pylori对抗生素的耐药性与患者的性别、年龄及临床转归无关。pylori对抗生素的敏感性在制定抗H.幽门相关疾病(C)2010年百世登。All rights reserved.
AIM: To investigate the resistance of Helicobacter pylori (H. pylon) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai.METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution.RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone. The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients.CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori-associated diseases. (C) 2010 Baishideng. All rights reserved.