Targeted radiotherapy with gold nanoparticles: current status and future perspectives.
Targeted radiotherapy with gold nanoparticles: current status and future perspectives.
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DOI：
10.2217/nnm.14.55
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
Makrigiorgos GM
中科院分区：
文献类型：
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作者：
Ngwa W;Kumar R;Sridhar S;Korideck H;Zygmanski P;Cormack RA;Berbeco R;Makrigiorgos GM
放射治疗（RT）是用电离辐射治疗癌症和其他疾病。RT的最终目标是摧毁所有疾病细胞，同时保留健康组织。为了实现这一目标，RT在过去几十年中取得了显着进步，部分原因是新技术，包括：多叶准直器辅助调制辐射束，改进的计算机辅助逆向治疗计划，图像引导，机器人更精确，更好的运动管理策略，立体定向治疗和低分割。随着纳米技术的最新进展，正在积极研究使用金纳米颗粒（GNP）的靶向RT，以进一步提高RT治疗率。在这篇综述中，我们总结了目前的研究和发展的现状，对使用GNP，以提高RT。我们强调有前途的新兴模式，有针对性的RT与GNP和相应的临床前证据支持这种承诺对潜在的临床翻译。未来的前景和展望进行了讨论。
Radiation therapy (RT) is the treatment of cancer and other diseases with ionizing radiation. The ultimate goal of RT is to destroy all the disease cells while sparing healthy tissue. Towards this goal, RT has advanced significantly over the past few decades in part due to new technologies including: multileaf collimator-assisted modulation of radiation beams, improved computer-assisted inverse treatment planning, image guidance, robotics with more precision, better motion management strategies, stereotactic treatments and hypofractionation. With recent advances in nanotechnology, targeted RT with gold nanoparticles (GNPs) is actively being investigated as a means to further increase the RT therapeutic ratio. In this review, we summarize the current status of research and development towards the use of GNPs to enhance RT. We highlight the promising emerging modalities for targeted RT with GNPs and the corresponding preclinical evidence supporting such promise towards potential clinical translation. Future prospects and perspectives are discussed.