An Electrochemical Method for Deborylative Hydroxylation of Arylboronic Acids under Metal‐free Conditions
An Electrochemical Method for Deborylative Hydroxylation of Arylboronic Acids under Metal‐free Conditions
复制标题
无金属条件下芳基硼酸脱硼羟基化的电化学方法
DOI：
10.1002/asia.202200780
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Hu Cai
中科院分区：
文献类型：
--
作者：
Zhengjiang Fu;Xuezheng Yi;Ziqi Fang;Tingting Zhong;Dongdong He;Shengmei Guo;Hu Cai
通过芳基硼的脱硼羟基化反应合成（多）酚的电化学方法已在无金属条件下得到很好的建立，其实用性和优势已通过药物分子的制备和可规模化转化的预形成而突出。机理研究表明，超氧阴离子自由基参与了转化，然后与芳基硼酸底物反应。
An electrochemical method for the synthesis of (poly)phenols via deborylative hydroxylation of arylborons has been well established under metal‐free conditions, whose practicability and advantage has been highlighted by the preparation of drug molecules and preformation of scalable transformation. Mechanistic studies have demonstrated that superoxide anion radical was involved in the conversion followed by the reaction with arylboronic acid substrate.