Differential effects of estrogen on hippocampal- and striatal-dependent learning
Differential effects of estrogen on hippocampal- and striatal-dependent learning
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DOI：
10.1016/j.nlm.2005.06.004
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发表时间：
2005-09-01
影响因子：
2.7
通讯作者：
Mizumori, SJY
中科院分区：
文献类型：
--
作者：
Davis, DM;Jacobson, TK;Mizumori, SJY
雌激素在学习和记忆中的作用可能是使动物倾向于使用特定的认知策略(Korol&Kolo，2002)。具体地说，雌激素可以促进海马体依赖的学习，同时也会减弱纹状体依赖的学习。作为对这一假说的严格检验，我们比较了去卵巢(OVX)雌性Long-Evans大鼠和长期雌激素替代(OVX+E；5 mg 17-β雌二醇60天缓释片)大鼠在八臂径向迷宫上的位置或反应学习。参考记忆错误和工作记忆错误分别用于位置学习任务和反应学习任务。OVX+E大鼠学习地点任务的速度明显快于反应任务，而且比OVX大鼠快。与OVX+E大鼠相比，OVX大鼠在反应任务中达到标准所需的时间更短。雌激素选择性地增强参考记忆能力，但仅限于位置学习。雌激素对学习的影响的特定模式表明，未来的研究包括验证动物使用的认知策略。(C)2005 Elsevier Inc.保留所有权利。
Estrogen's role in learning and memory may be to predispose animals to use specific cognitive strategies (Korol & Kolo, 2002). Specifically, estrogen may facilitate hippocampal-dependent learning, while at the same time attenuate striatal-dependent learning. As a stringent test of this hypothesis, place or response learning on an eight-arm radial maze was compared between ovariectomized (OVX) female Long-Evans rats and rats with chronic estrogen replacement (OVX + E; 5 mg 17-beta estradiol 60-day release tablet). Reference and working memory errors were monitored separately for both place and response learning tasks. OVX + E rats learned the place task significantly faster than the response task, and faster than OVX rats. OVX rats required fewer days to reach criterion on the response task than OVX + E rats. Estrogen selectively enhanced reference memory performance, but only during place learning. The specific pattern of estrogen effects on learning suggests that future studies include verification of cognitive strategies used by animals. (c) 2005 Elsevier Inc. All rights reserved.