Staphylococcus aureus vaccine against mastitis in dairy cows, composition and evaluation of its immunogenicity in a mouse model
Staphylococcus aureus vaccine against mastitis in dairy cows, composition and evaluation of its immunogenicity in a mouse model
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DOI：
10.1016/s0165-2427(03)00069-2
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发表时间：
2003-06-20
影响因子：
1.8
通讯作者：
Trainin, Z
中科院分区：
文献类型：
--
作者：
Leitner, G;Lubashevsky, E;Trainin, Z
由金黄色葡萄球菌（S.金黄色葡萄球菌）是影响产奶质量和数量的最重要的感染性疾病。乳房内使用的抗生素治疗通常不能成功地消除现有的S。金黄色葡萄球菌感染接种疫苗是控制沙门氏菌的合理途径。金黄色乳房感染。然而，迄今为止，商业上可获得的S.金黄色葡萄球菌疫苗在田间条件下显示出有限的效力，这主要是由于缺乏关于将诱导广谱免疫的相关抗原的信息。本文描述了研制一种新疫苗MASTIVAC I的尝试。MASTIVAC I由S.金黄色葡萄球菌，即：VLVL 8407：ZO 3984和BS 449，它们分离自牛乳房炎的临床和亚临床病例。小鼠模型用于评价S.金黄色葡萄球菌特异性抗体的产生和小鼠对强毒金黄色葡萄球菌的保护。金黄色葡萄球菌获得的结果表明，该疫苗表现出广谱的抗原性和免疫原性，可保护小鼠免受同源物和异源物的侵害。金黄色葡萄球菌攻击。(C)2003 Elsevier Science B.V.保留所有权利。
Bovine mastitis caused by Staphylococcus aureus (S. aureus) is a most important infection disease that affects both the quality and the quantity of milk production. Antibiotic therapies formulated for intramammary use are generally unsuccessful in eliminating existing S. aureus infections. Vaccination is a logical approach to the control of S. aureus udder infections. However, to date commercially available S. aureus vaccine have shown limited efficacy under field conditions, mainly due to the paucity of information regarding relevant antigens which will induce a broad spectrum immunization. In the present paper the attempt to develop a new vaccine designated MASTIVAC I is described. MASTIVAC I is composed of three strains of S. aureus namely: VLVL8407: ZO3984 and BS449 which were isolated from clinical and sub-clinical cases of bovine mastitis. A mouse model was used to evaluate the S. aureus specific antibody production and protection of mice against virulent S. aureus strains. The results obtained showed that this vaccine exhibits a broad spectrum of antigenic and immunogenic properties that protects mice from homologues and hetrologous S. aureus challenge. (C) 2003 Elsevier Science B.V. All rights reserved.