Long-term Outcome of Chondrosarcoma: A Single Institutional Experience.
Long-term Outcome of Chondrosarcoma: A Single Institutional Experience.
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DOI：
10.4143/crt.2014.135
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发表时间：
2015-10
影响因子：
4.6
通讯作者：
Kim HS
中科院分区：
文献类型：
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作者：
Bindiganavile S;Han I;Yun JY;Kim HS
软骨肉瘤的预后因素仍然不确定，因为只有少数长期随访的大型研究报告。本研究的目的是分析肿瘤学结果和预后因素。我们对125例在本机构接受手术的软骨肉瘤患者的肿瘤学结局和预后因素进行了回顾性分析。5年、10年和15年的总生存率分别为91.6%± 2.5%、84.1% ± 3.8%和84.1%±3.8%。在组织学类型中，去分化型的生存率最低（p < 0.001）。传统型软骨肉瘤的预后与组织学分级和解剖位置有关，轴位高分级者预后最差（p < 0.001）。相比之下，低级别的软骨肉瘤的关节软骨可以安全地治疗病灶内刮除术。组织学类型与软骨肉瘤的预后显著相关。对于常规型，组织学分级和解剖位置预测结果，轴向位置的高级别具有最差的结果。
The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution. Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome.