White matter impairment in chronic heroin dependence: A quantitative DTI study
White matter impairment in chronic heroin dependence: A quantitative DTI study
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慢性海洛因依赖导致的白质损伤：定量 DTI 研究
DOI：
10.1016/j.brainres.2013.07.036
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发表时间：
2013-09-19
期刊：
影响因子：
2.9
通讯作者：
Wang, Wei
中科院分区：
文献类型：
--
作者：
Li, Wei;Li, Qiang;Wang, Wei
暴露于成瘾药物与大脑白色物质完整性的破坏有关。有几项研究检查了海洛因使用者的白色缺陷;然而，结果受到美沙酮和丁丙诺啡等替代药物使用的影响。本研究采用定量扩散张量成像（DTI）评估了未接受任何替代治疗的海洛因依赖者的白色物质完整性和海洛因相关神经病理学的改变。该研究包括17名海洛因依赖（HD）受试者和15名匹配的健康对照（HC）。采用基于体素的分析方法，测量并比较了全脑白色物质的各向异性分数（FA）和特征值（λ（垂直于），λ（平行于））。用偏相关分析法检验所确定区域的DTI测量值与海洛因暴露史之间的相关性。HD组双侧额叶次回、扣带回、内侧额回、核外区、左侧颞叶次回、右侧额上上级回FA值较HC组明显降低。在这些区域中，相对于HC组，HD组在双侧额叶亚脑回、扣带回和核外区域的λ（垂直于）显著增加。lambda（平行于）无组间差异。此外，海洛因使用的持续时间或累积剂量和FA或λ（垂直）值之间没有显着的相关性。总之，慢性海洛因依赖受试者的白色物质结构连接的广泛破坏主要位于大脑的前部和上级区域。髓鞘而非轴突的损伤是海洛因使用者脑中的主要病理特征。(C)2013爱思唯尔有限公司版权所有。
Exposure to addictive drugs has been associated with disrupted brain white matter integrity. A few studies have examined the white matter deficits in heroin users; however, the results were influenced by the use of substitution drugs such as methadone and buprenorphine. The present study assessed the alteration in white matter integrity and heroin-related neuropathology in heroin dependents who had not received any replacement therapy using quantitative diffusion tensor imaging (DTI). The study comprised 17 heroin-dependent (HD) subjects and 15 matched healthy controls (HC). Fractional anisotropy (FA) and eigenvalues (lambda(perpendicular to), lambda(parallel to)) of white matter in the whole brain were measured and compared using a voxel-based analysis. The correlation between DTI measurements in identified regions and history of heroin exposure was tested by partial correlation analysis. Compared with HCs, HD subjects displayed decreased FA in the bilateral frontal lobe sub-gyrus, cingulate gyms, medial frontal gyms, extra-nuclear, left temporal lobe sub-gyms and right superior frontal gyrus. Among these regions, the HD group had significantly increased lambda(perpendicular to) in the bilateral frontal lobe subgyms, thngulate gyrus and extra-nuclear relative to the HC group. There were no group differences in lambda(parallel to). In addition, there were no significant correlations between duration of heroin use or accumulated dosage and FA or lambda(perpendicular to) values. In conclusion, chronic heroin-dependent subjects had widespread disruption of white matter structural connectivity located mainly in anterior and superior regions of the brain. Damage to myelin other than axons was the primary pathological feature in the brain of the heroin user. (C) 2013 Elsevier B.V. All rights reserved.