Primary progressive aphasia: PPA and the language network.
Primary progressive aphasia: PPA and the language network.
复制标题
原发性进行性失语：PPA 和语言网络。
DOI：
10.1002/ana.10390
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发表时间：
2003
影响因子：
11.2
通讯作者：
Gitelman,DarrenR
中科院分区：
文献类型：
--
作者：
Sonty,SreepadmaP;Mesulam,M-Marsel;Thompson,CynthiaK;Johnson,NancyA;Weintraub,Sandra;Parrish,ToddB;Gitelman,DarrenR
原发性进行性失语症 (PPA) 是一种行为局灶性痴呆综合征，至少在疾病的前两年内，语言功能恶化，但其他认知领域相对保留。在这项研究中，使用基于体素的形态测量（VBM）和功能磁共振成像（fMRI）对单词发现受损但对会话言语的理解完整的 PPA 患者及其匹配的对照受试者进行了检查。功能磁共振成像将语音和语义语言任务期间的信号变化与控制任务（匹配字母）期间的信号变化进行了比较。与对照组相比，PPA 患者在语言任务上表现出更长的反应时间和更低的准确性，但在控制任务上没有表现差异。 VBM 显示 PPA 组左上颞叶和下顶叶区域的灰质减少。然而，这些患者在古典语言区域内表现出正常的激活模式。此外，PPA 患者的梭状回、中央前回和顶内沟出现了正常人未见的激活。研究发现这些激活与命名和任务绩效的测量呈负相关。因此，PPA 中的额外激活可能代表了语言相关神经活动的补偿性扩散，或者未能抑制在语言任务期间通常受到抑制的区域的活动。安·尼罗尔 2003；53:000–000
Primary Progressive Aphasia (PPA) is a behaviorally focal dementia syndrome with deterioration of language functions but relative preservation of other cognitive domains for at least the first two years of disease. In this study, PPA patients with impaired word finding but intact comprehension of conversational speech and their matched control subjects were examined using voxel‐based morphometry (VBM) and functional magnetic resonance imaging (fMRI). fMRI compared signal changes during phonological and semantic language tasks with those during a control task (matching letters). PPA patients showed longer reaction times and reduced accuracy versus controls on the language tasks, but no performance differences on the control task. VBM demonstrated reduced gray matter in left superior temporal and inferior parietal regions in the PPA group. However, these patients showed a normal pattern of activation within the classical language regions. In addition, PPA patients showed activations, not seen in normals, in fusiform gyrus, precentral gyrus, and intra‐parietal sulcus. These activations were found to correlate negatively with measures of naming and task performance. The additional activations in PPA may therefore represent a compensatory spread of language‐related neural activity or a failure to suppress activity in areas normally inhibited during language tasks. Ann Neurol 2003;53:000–000