Trials for Cerebellar Ataxias - From Cellular Models to Human Therapies
Trials for Cerebellar Ataxias - From Cellular Models to Human Therapies
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小脑性共济失调试验 - 从细胞模型到人类疗法
DOI：
10.1007/978-3-031-24345-5_2
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Pickford J
中科院分区：
文献类型：
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作者：
Pickford J
小脑通常与运动控制有关，尽管现在有广泛的证据表明它的参与扩展到其他领域，包括认知处理。小脑包含一个高度规则的神经组织，但这个回路究竟如何促进其多样化的功能仍不清楚。小脑的输入和输出模式，以及小脑内的连接，增加了小脑计算的复杂性，这些计算在解剖学和生理学定义的模块之间可能存在差异。因此，不同的模块可能专门用于不同的功能，例如平衡和运动与伸手抓握。然而，小脑在控制运动和认知行为中的统一作用可能是作为一种预测装置，根据实际结果改进这些预测，以提高行为表现。
The cerebellum is typically associated with motor control although there is now extensive evidence that its involvement extends into other domains including cognitive processing. The cerebellum contains a highly regular neural organization, but exactly how this circuitry contributes to its diverse functions remains unclear. Patterns of inputs to and outputs from the cerebellum, together with intracerebellar connections, add layers of complexity to cerebellar computations that can differ between anatomically and physiologically defined modules. Different modules are therefore likely to be specialized for different functions, for example in balance and locomotion versus reach-to-grasp. However, the unifying role of the cerebellum in the control of motor and cognitive behavior may be to serve as a prediction device, refining these predictions based on actual outcomes, to enhance behavioral performance.