Striatal beta-amyloid deposition in Parkinson disease with dementia.
Striatal beta-amyloid deposition in Parkinson disease with dementia.
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DOI：
10.1097/nen.0b013e3181713cb1
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发表时间：
2008-05
影响因子：
3.2
通讯作者：
K. Jellinger
中科院分区：
文献类型：
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作者：
K. Jellinger
在最近的一篇文章中，Kalaitzakis et al（1）报告了帕金森病（PD）伴痴呆（PDD）患者纹状体中淀粉样β肽（Aβ）负荷显著高于非痴呆PD患者，而α-突触核蛋白（αSN）和tau沉积在两组中同样罕见。由于两组中神经炎性Braak分期均相当低，因此得出结论，纹状体中的Aβ沉积与阿尔茨海默病（AD）变化类型无关，与PD中的痴呆密切相关。这些数据至少部分可以从64例路易体病（21例PD，23例PDD和20例路易体痴呆[DLB]）的个人尸检系列结果中得到证实。根据标准化方法进行神经病理学评估。使用常规染色和免疫组织化学检查多个石蜡包埋组织块的tau、Aβ（克隆4G 8）和αSN。…
In a recent article, Kalaitzakis et al (1) reported a significantly greater amyloid-β peptide (Aβ) burden in the striatum of cases of Parkinson disease (PD) with dementia (PDD) than in nondemented PD patients, whereas α-synuclein (αSN) and tau deposition were similarly rare in both groups. Because neuritic Braak stages were rather low in both groups, it was concluded that Aβ deposition in the striatum, which was type independent of Alzheimer disease (AD) changes, strongly correlates with dementia in PD. These data can, at least in part, be confirmed from the results of a personal autopsy series of 64 cases of Lewy body disease (21 PD, 23 PDD, and 20 dementia with Lewy bodies [DLB]). Neuropathologic assessment was performed according to standardized methods. Multiple paraffin-embedded blocks were examined using routine stains and immunohistochemistry for tau, Aβ (clone 4G8), and αSN. …