Tissue interaction is required for glenoid fossa development during temporomandibular joint formation.
Tissue interaction is required for glenoid fossa development during temporomandibular joint formation.
复制标题
DOI：
10.1002/dvdy.22748
复制
发表时间：
2011-11
影响因子：
2.5
通讯作者：
Chen, YiPing
中科院分区：
文献类型：
--
作者：
Wang, Ying;Liu, Chao;Rohr, Joseph;Liu, Hongbing;He, Fenglei;Yu, Jian;Sun, Cheng;Li, Lu;Gu, Shuping;Chen, YiPing
哺乳动物的颞下颌关节（TMJ）是由两种不同的间质凝聚形成的，它们相互生长并通过不同的机制骨化，其中盂窝是膜内骨化，而髁突是软骨内骨化。在这项研究中，我们使用了多种转基因小鼠模型来研究小鼠TMJ形成过程中髁突和盂窝之间的组织相互作用。我们报告，无论是缺少或脱位的髁导致一个逮捕的盂窝发展。在这两种情况下，关节窝的发展都是开始的，但未能维持，并随后退化。然而，髁突的发育似乎与形成的盂窝的存在无关。此外，我们发现用梅克尔软骨代替髁突能够维持盂窝的发育。这些观察结果表明，来自发育中的髁突或梅克尔软骨的适当信号是维持盂窝发育所必需的。
The mammalian temporomandibular joint (TMJ) develops from two distinct mesenchymal condensations that grow towards each other and ossify through different mechanisms, with the glenoid fossa undergoing intramembranous ossification while the condyle being endochondral in origin. In this study, we used various genetically modified mouse models to investigate tissue interaction between the condyle and glenoid fossa during TMJ formation in mice. We report that either absence or dislocation of the condyle results in an arrested glenoid fossa development. In both cases, glenoid fossa development was initiated, but failed to sustain, and became regressed subsequently. However, condyle development appears to be independent upon the presence of the forming glenoid fossa. In addition, we show that substitution of condyle by Meckel’s cartilage is able to sustain glenoid fossa development. These observations suggest that proper signals from the developing condyle or Meckel’s cartilage are required to sustain the glenoid fossa development.
登录
查看更多内容
影响因子：
7.6
作者：
Ochiai T;Shibukawa Y;Nagayama M;Mundy C;Yasuda T;Okabe T;Shimono K;Kanyama M;Hasegawa H;Maeda Y;Lanske B;Pacifici M;Koyama E
通讯作者：
Koyama E
影响因子：
10.5
作者：
Akiyama, H;Chaboissier, MC;de Crombrugghe, B
通讯作者：
de Crombrugghe, B
DOI：
10.1016/0002-9416(75)90207-9
发表时间：
1975-01-01
影响因子：
3
作者：
BERESFORD, WA
通讯作者：
BERESFORD, WA
影响因子：
3.3
作者：
Ogawa, T;Shimokawa, H;Kuroda, T
通讯作者：
Kuroda, T
DOI：
10.1007/s00429-004-0393-2
发表时间：
2004-07-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Shibata, S;Suda, N;Komori, T
通讯作者：
Komori, T