Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors
Striatal Dopamine Modulates Basal Ganglia Output and Regulates Social Context-Dependent Behavioral Variability through D1 Receptors
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DOI：
10.1523/jneurosci.5974-09.2010
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发表时间：
2010-04-21
影响因子：
5.3
通讯作者：
Perkel, David J.
中科院分区：
文献类型：
--
作者：
Leblois, Arthur;Wendel, Benjamin J.;Perkel, David J.
皮质-基底神经节（BG）回路被认为通过强化学习促进运动技能的获得。在鸣禽中，BG的一个专门部分负责歌曲学习和可塑性。该电路产生的歌曲的变化，基础声乐实验在幼鸟和调制歌曲的变化，这取决于在成年鸟类的社会背景。当雄鸟在雌鸟存在下唱歌时，与BG诱导的歌曲变异性降低相关的社会背景，细胞外多巴胺（DA）水平在鸟类BG核X区增加。这些结果表明，DA可能通过其在X区的作用而触发鸣唱变异性的变化。与这一假设相一致，我们报告说，DA提供给X区削弱了输出信号的禽皮质BG电路。DA通过D-1受体起作用，减少X区对歌曲播放和对其传入皮层核HVC（用作专有名称）的电刺激的反应。具体而言，DA减少了对直接兴奋性输入的反应，并降低了向丘脑提供输出的苍白球X区神经元的放电变异性。因此，DA在X区的交付也降低了对歌曲播放的反应，在皮层输出核的BG环，外侧大细胞核的前巢皮质。此外，干扰X区域的D-1受体传递，消除了与社会背景相关的歌曲变异性变化。总之，我们认为DA作用于X区的D-1受体，以调节BG输出信号并触发歌曲变异性的变化。
Cortico-basal ganglia (BG) circuits are thought to promote the acquisition of motor skills through reinforcement learning. In songbirds, a specialized portion of the BG is responsible for song learning and plasticity. This circuit generates song variability that underlies vocal experimentation in young birds and modulates song variability depending on the social context in adult birds. When male birds sing in the presence of a female, a social context associated with decreased BG-induced song variability, the extracellular dopamine (DA) level is increased in the avian BG nucleus Area X. These results suggest that DA could trigger song variability changes through its action in Area X. Consistent with this hypothesis, we report that DA delivered to Area X weakens the output signal of the avian cortico-BG circuit. Acting through D-1 receptors, DA reduced responses in Area X to song playback and to electrical stimulation of its afferent cortical nucleus HVC (used as a proper name). Specifically, DA reduced the response to direct excitatory input and decreased firing variability in Area X pallidal neurons, which provide the output to the thalamus. As a consequence, DA delivery in Area X also decreased responses to song playback in the cortical output nucleus of the BG loop, the lateral magnocellular nucleus of the anterior nidopallium. Further, interfering with D-1 receptor transmission in Area X abolished social context-related changes in song variability. In conclusion, we propose that DA acts on D-1 receptors in Area X to modulate the BG output signal and trigger changes in song variability.