Gender features and estrous cycle variations of nocturnal behavior of mice after a single exposure to light at night
Gender features and estrous cycle variations of nocturnal behavior of mice after a single exposure to light at night
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DOI：
10.1016/j.physbeh.2016.05.049
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发表时间：
2016-10-01
影响因子：
2.9
通讯作者：
Chakrabarti, Nilkanta
中科院分区：
文献类型：
--
作者：
Datta, Siddhartha;Samanta, Diptaman;Chakrabarti, Nilkanta
夜晚的光线会改变啮齿动物的行为和认知表现，而这些变化在性别和雌性生殖周期阶段的变化是难以捉摸的。采用新颖的目标识别任务，对习惯了光：暗（12:12 h）周期的幼鼠进行夜间单次光照（100 lx） 1小时，然后分别在开阔场地（封闭墙壁加圆形大舞台）、高架加迷宫和方形场地进行记忆测试。光效比较了无光条件下的结果。与没有光照的雌性相比，发情的雌性在夜间表现出更大的运动活动，更少的焦虑和更好的记忆表现。在没有光照的情况下，雄性小鼠在夜间的运动活动、焦虑和记忆表现的状态似乎与雌性小鼠相当，而雌性小鼠的发情周期阶段是表征雄性小鼠夜间行为的重要因素。光照对发情期女性的影响最大，表现为运动活动减少、焦虑增加和记忆能力下降。光照后，雄性和雌性小鼠的运动活动和焦虑都没有改变，而雄性小鼠的记忆表现更好，运动活动和焦虑也更大。本研究研究了光照条件下和光照条件下小鼠夜间行为的性别特征和发情周期变化。此外，该研究表明记忆表现与小鼠夜间行为的运动活动和焦虑有关。(C) 2016 Elsevier Inc.版权所有。
Light at night alters behavior and cognitive performances in rodents, the variations of which in gender and stages of reproductive cycle in females are elusive. Young mice habituated in light:dark (12:12 h) cycle were given a single exposure of light (100 lx) at early night for one hour duration followed by experimentations in open field (closed wall with circular big arena), elevated plus maze and square habituated field for memory performance using novel object recognition task. Light effects were compared with results found during without light conditions. Proestrous females appeared to have greater locomotor activity, less anxiety and better memory performance compared to the diestrous females at night without light exposure. The status of locomotor activity, anxiety and memory performance of male mice at night without light exposure appeared to be comparable to females where the stage of estrous cycle is important to characterize the nocturnal behavior of male mice. Light maximally affected proestrous females with decrease in locomotor activity, increase in anxiety and failure of memory performance. Male and diestrous female mice performed memory performance without alteration of locomotor activity and anxiety after exposure to light where males performed better memory performance with greater locomotor activity and more anxiety compared to that of diestrous females. The present study characterizes the mice nocturnal behavior with and without a single exposure to light stimuli with its gender features and estrous cycle variation. In addition, the study indicates an association of memory performance with locomotor activity and anxiety in mice nocturnal behavior. (C) 2016 Elsevier Inc. All rights reserved.