The Sensory Innervation of the Human Pharynx: Searching for Mechanoreceptors
The Sensory Innervation of the Human Pharynx: Searching for Mechanoreceptors
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DOI：
10.1002/ar.22792
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发表时间：
2013-11-01
影响因子：
2
通讯作者：
Vega, J. A.
中科院分区：
文献类型：
--
作者：
de Carlos, F.;Cobo, J.;Vega, J. A.
上气道肌肉的协调神经调节是控制气道大小和阻力的基础。上级缩咽肌（SCPM）形成咽的侧壁和后壁的主要部分，并且通常没有肌梭，肌梭是本体感受器的主要类型。由于SCPM引起的本体感觉在上呼吸道的生理学中具有潜在的重要性，因此我们研究了是否存在机械感觉神经末梢替代肌梭。使用与一般轴突和雪旺细胞标志物（NSE、PGP 9.5、RT-97和S100 P）、梭内肌纤维标志物和推定的机械义蛋白（TRPV 4和ASIC 2）相关的免疫组织化学分析人咽部样品。在咽壁中观察到不同种类的感觉小体（Pacini样小体、Ruffini样小体、螺旋码头神经结构等），其由感觉神经供应并表达推定的机械蛋白。没有观察到肌梭的证据。目前的结果表明，在人类咽部的感觉小体/mechanoreceptors，推测检测上呼吸道的机械变化，并取代肌梭本体感觉的许多和不同的形态发生。目前的研究结果是潜在的利益的知识上呼吸道的病理与假定的感觉发病机制。Anat Rec，296：1735-1746，2013。(c)2013 Wiley Periodicals，Inc.
The coordinate neural regulation of the upper airways muscles is basic to control airway size and resistance. The superior constrictor pharyngeal muscle (SCPM) forms the main part of the lateral and posterior walls of the pharynx and typically is devoid of muscle spindles, the main type of proprioceptor. Because proprioception arising from SCPM is potentially important in the physiology of the upper airways, we have investigated if there are mechanical sensory nerve endings substitute for the muscle spindles. Samples of human pharynx were analyzed using immunohistochemistry associated to general axonic and Schwann cells markers (NSE, PGP 9.5, RT-97, and S100P), intrafusal muscle fiber markers, and putative mechanical sense proteins (TRPV4 and ASIC2). Different kinds of sensory corpuscles were observed in the pharynx walls (Pacini-like corpuscles, Ruffini-like corpuscles, spiral-wharves nerve structures, and others) which are supplied by sensory nerves and express putative mechanoproteins. No evidence of muscle spindles was observed. The present results demonstrate the occurrence of numerous and different morphotypes of sensory corpuscles/mechanoreceptors in human pharynx that presumably detect mechanical changes in the upper airways and replace muscle spindles for proprioception. Present findings are of potential interest for the knowledge of pathologies of the upper airways with supposed sensory pathogenesis. Anat Rec, 296:1735-1746, 2013. (c) 2013 Wiley Periodicals, Inc.