Mizuno H, Koya J, Fujioka Y, Ibaraki T, Nakamura F, Hayashi A, Shinozaki-Ushiku A, Akamatsu N, Hasegawa K, Kokudo N, Fukuyama M, Kurokawa M.
Mizuno H, Koya J, Fujioka Y, Ibaraki T, Nakamura F, Hayashi A, Shinozaki-Ushiku A, Akamatsu N, Hasegawa K, Kokudo N, Fukuyama M, Kurokawa M.
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Mizuno H、Koya J、Fujioka Y、Ibaraki T、Nakamura F、Hayashi A、Shinozaki-Ushiku A、Akamatsu N、Hasekawa K、Kokudo N、Fukuyama M、Kurokawa M。
DOI：
10.1007/s00277-017-2969-y
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Extranodal NK/T cell lymphoma in a living donor liver transplant recipient.
中科院分区：
文献类型：
--
作者：
Saito R;Abe H;Kunita A;Yamashita H;Seto Y;Fukayama M;Extranodal NK/T cell lymphoma in a living donor liver transplant recipient.
尊敬的编辑先生，以往的文献表明，实体器官移植后非霍奇金淋巴瘤中有0.5-8.3%是NK/T细胞淋巴瘤[1，2]。虽然已有一些肾移植后结外NK/T细胞淋巴瘤，鼻型(ENKL)的报道[1，3-6]，但到目前为止还没有肝移植后ENKL的报道。她曾在9年前接受活体供肝移植治疗慢性丙型肝炎合并肝硬变，并一直服用免疫抑制剂以防止同种异体移植排斥反应。为此，我们通常使用他克莫司和甲基强的松龙；然而，在这种情况下，由于难治性腹泻，我们将他克莫司改为霉酚酸酯。切开的牙龈活检样本显示中等大小的非典型淋巴样细胞浸润。免疫组织化学染色：CD_3(+)、CD_4(−)、CD_5(弱)、CD_8(+)、CD_(20)(−)、CD_(56)(弱)。EB病毒编码的RNA原位杂交(EBER-ISH)结果为阳性。增强CT扫描显示腹主动脉旁淋巴结肿大和左肾旁肿瘤。氟脱氧葡萄糖正电子
Dear Editor, Previous literatures showed that 0.5–8.3% of non-Hodgkin lymphomas after solid organ transplantation were NK/T cell lymphomas [1, 2]. Although some cases of extranodal NK/T cell lymphoma, nasal type (ENKL) after kidney transplantation were reported [1, 3–6], ENKL after liver transplantation has not been reported so far.A 62-year-old woman presented with progressive gingival ulcers in the upper jaw. She had undergone living donor liver transplantation for liver cirrhosis with chronic hepatitis C 9 years before and had been taking immunosuppressants for prevention of allograft rejection. We usually use tacrolimus and methylprednisolone for this purpose; however, in this case, we changed tacrolimus to mycophenolate mofetil due to refractory diarrhea. Incisional biopsy sample of the gingiva showed middle-sized atypical lymphoid cell infiltration. In immunohistochemical staining, these lymphoid cells were CD3 (+), CD4 (−), CD5 (weak), CD8 (+), CD20 (−), and CD56 (weak). Epstein-Barr virus-encoded RNA in situ hybridization (EBER-ISH) gave a positive result. Contrast-enhanced computed tomography scan revealed paraaortic lymph nodes swelling and a left pararenal tumor. Fluorodeoxyglucose positron