Parathyroid hormone - a drug for orthopedic surgery?
Parathyroid hormone - a drug for orthopedic surgery?
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DOI：
10.1080/00016470410004012
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发表时间：
2004-12-01
期刊：
影响因子：
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通讯作者：
Aspenberg, P
中科院分区：
文献类型：
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作者：
Skripitz, R;Aspenberg, P
尽管连续暴露于PTH导致骨吸收，但间歇剂量给药通过增加成骨细胞数量和活性导致骨形成。PTH的合成代谢作用也已在临床试验中得到证实，其中PTH增加骨质疏松症患者的骨量并降低骨折率。在骨折愈合和骨科植入物固定的动物模型中，PTH以剂量依赖性方式增加骨密度，导致更快的修复和更好的固定。对新形成的骨骼的影响似乎比对原有骨骼的影响更强。基于这些临床前研究，我们认为间歇性PTH治疗也可能有利于患者的骨折愈合和植入物固定。
Whereas continuous exposure to PTH results in bone resorption, administration at intermittent doses results in bone formation by increasing osteoblast number and activity. The anabolic action of PTH has also been demonstrated in clinical trials, in which PTH increased the bone mass and reduced fracture rate in patients with osteoporosis. In animal models of fracture healing and fixation of orthopedic implants, PTH increases the bone density in a dose-dependent manner, leading to faster repair and better fixation. The effect appears to be stronger on the new forming bone than on pre-existing bone. Based on these preclinical studies, we suggest that intermittent PTH treatment may also benefit fracture healing and implant fixation in patients.