Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus
Mitochondrial bioenergetics, mass, and morphology are altered in cells of the degenerating human annulus
复制标题
DOI：
10.1002/jor.22361
复制
发表时间：
2013-08-01
影响因子：
2.8
通讯作者：
Hanley, Edward N., Jr.
中科院分区：
文献类型：
--
作者：
Gruber, Helen E.;Watts, John A.;Hanley, Edward N., Jr.
背痛和椎间盘退变对社会经济健康的影响越来越大。然而，关于人类椎间盘细胞中线粒体功能的信息令人惊讶地稀少。我们评估了从不同退行性阶段的人类椎间盘培养的纤维环细胞中的线粒体生物能量学、质量和超微结构。柠檬酸合酶活性（反映线粒体质量）随着Thompson分级的增加而显著下降（p
Back pain and intervertebral disc degeneration have a growing socioeconomic healthcare impact. Information on mitochondrial function in human intervertebral disc cells, however, is surprisingly sparse. We assessed mitochondrial bioenergetics, mass, and ultrastructure in annulus cells cultured from human discs of varying degenerative stages. Citrate synthase activity (reflecting mitochondrial mass) declined significantly with increasing Thompson grade (p