Resting state fMRI in Alzheimer's disease: beyond the default mode network
Resting state fMRI in Alzheimer's disease: beyond the default mode network
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DOI：
10.1016/j.neurobiolaging.2011.06.007
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发表时间：
2012-08-01
影响因子：
4.2
通讯作者：
Filippi, Massimo
中科院分区：
文献类型：
--
作者：
Agosta, Federica;Pievani, Michela;Filippi, Massimo
采用静息状态（RS）功能磁共振成像（fMRI）技术，研究了13例阿尔茨海默病（AD）患者、12例遗忘性轻度认知障碍（aMCI）患者和13例健康对照者的默认模式（DMN）、额顶叶、执行和显著性网络的连通性模式。与对照组和aMCI相比，AD与DMN（减少）和额叶网络（增强）的相反连通性效应相关。与对照组相比，aMCI患者中发现的唯一RS异常是DMN楔前叶连通性降低。RS fMRI组差异仅与灰质萎缩部分相关。在AD患者中，平均执行网络连通性与额叶-执行和语言神经心理学得分呈正相关。这些结果表明，阿尔茨海默病与大规模功能性脑网络的改变有关，这种改变远远超出了DMN。在阿尔茨海默病中，DMN有限的资源可能与前额叶连接的增加相平行，以维持认知效率。内侧顶叶RS fMRI信号改变似乎自AD早期就存在。(C) 2012爱思唯尔公司版权所有。
Using resting state (RS) functional magnetic resonance imaging (fMRI), the connectivity patterns of the default mode (DMN), frontoparietal, executive, and salience networks were explored in 13 Alzheimer's disease (AD) patients, 12 amnestic mild cognitive impairment (aMCI) patients, and 13 healthy controls. Compared with controls and aMCI, AD was associated with opposing connectivity effects in the DMN (decreased) and frontal networks (enhanced). The only RS abnormality found in aMCI patients compared with controls was a precuneus connectivity reduction in the DMN. RS fMRI group differences were only partly related to gray matter atrophy. In AD patients, the mean executive network connectivity was positively associated with frontal-executive and language neuropsychological scores. These results suggest that AD is associated with an alteration of large-scale functional brain networks, which extends well beyond the DMN. In AD, the limited resources of the DMN may be paralleled, in an attempt to maintain cognitive efficiency, by an increased prefrontal connectivity. A medial parietal RS fMRI signal change seems to be present since the early phase of AD. (C) 2012 Elsevier Inc. All rights reserved.