Bacterial Infection: The Main Cause of Acute Cholestasis in Newborn Infants Receiving Short‐Term Parenteral Nutrition
Bacterial Infection: The Main Cause of Acute Cholestasis in Newborn Infants Receiving Short‐Term Parenteral Nutrition
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细菌感染：接受短期肠外营养的新生儿急性胆汁淤积的主要原因
DOI：
10.1097/00005176-198904000-00006
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发表时间：
1989
影响因子：
2.9
通讯作者：
F. Pohlandt
中科院分区：
文献类型：
--
作者：
A. Wolf;F. Pohlandt
为了检验细菌感染是短期静脉喂养新生儿急性胆汁淤积的主要原因这一假设，对两组进行了研究。第一组由 152 名新生儿组成，他们接受了至少 7 天的静脉喂养，并且出现了严重的细菌感染。第二组由 92 名新生儿组成，他们在出生年份、出生体重和胎龄、Apgar 评分和肠外营养持续时间方面与第一组病例相匹配，但没有感染。细菌感染的诊断依据是微循环受损、毛细血管充盈时间延长、白细胞分类左移以及血培养阳性。当血清总胆红素水平>4 mg/dl且结合部分占总量的40%以上时，诊断为胆汁淤积。结果，40例胆汁淤积病例全部出现在第一组感染婴儿中。所有其他因素在两组之间分布均等，不能归因于特发性新生儿胆汁淤积病因的主要因素。结论是细菌感染是静脉喂养新生儿急性胆汁淤积的主要原因。
To test the hypothesis that bacterial infections are the main cause of acute cholestasis in short-term intravenously fed newborns, two groups were studied. Group I consisted of 152 newborn infants who were fed intravenously for at least 7 days and in whom severe bacterial infections developed. Group II was formed of 92 newborn infants who were matched to the group I cases with respect to the year of birth, birth weight and gestational age, Apgar scores, and duration of parenteral nutrition but who did not have infections. Bacterial infections were diagnosed on the basis of impaired microcirculation with prolonged capillary filling time, a shift to the left in the white cell differential, and a positive blood culture. Cholestasis was diagnosed when the total serum bilirubin level was >4 mg/dl and the conjugated fraction made up more than 40% of the total. The results were that all 40 cases of cholestasis were found in the first group of infected infants. All of the other factors were distributed equally between both groups and could not be attributed as a major factor in the etiology of idiopathic neonatal cholestasis. The conclusion was that bacterial infections are the main cause of acute cholestasis in intravenously fed newborn infants.