Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c‐kit‐expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis
Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c‐kit‐expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis
复制标题
肝内胆管结石和原发性硬化性胆管炎中胆道上皮细胞上干细胞因子的异常表达以及表达 c-kit 的肥大细胞的胆周浸润：可能导致胆管纤维化
作者：
K. Tsuneyama;N. Kono;M. Yamashiro;W. Kouda;Amura Sabit;M. Sasaki;Y. Nakanuma
肝内胆管结石和原发性硬化性胆管炎是难治性慢性胆道疾病。在肝内胆管结石中，胆红素-钙结石被包裹在多个不规则扩张的肝内胆管中。在PSC中，终末会出现小的胆红素-钙结石。进行性胆管周围纤维化伴胆管扩张和狭窄可能是这两种疾病难以治愈的原因之一。本免疫组化研究探讨了肝胆管结石和PSC中可能参与纤维化的一些因子的表达。在肝内大胆管周围的导管周围和导管纤维化中以及增殖的胆管周围腺体中发现了许多c-kit阳性的肥大细胞。这些肥大细胞还表达碱性成纤维细胞生长因子和/或肿瘤坏死因子-α，它们被称为纤维发生因子。值得注意的是，在显示管周纤维化和炎症的扩张和狭窄胆管的胆管上皮以及肝内胆管结石和PSC中增殖的胆管周围腺体上证实了干细胞因子（SCF）（c-kit的配体）的异常表达，而在肝内胆管结石的未受影响胆管或正常肝脏的胆管中未观察到此类表达。表达SCF的胆管周围的一些浸润性单核细胞也呈SCF阳性。胆管上皮细胞上异常表达的SCF可能通过c-kit受体积累并刺激肥大细胞，这些上调的肥大细胞通过在肝胆管结石和PSC中显示纤维化因子诱导进行性导管周围和门静脉纤维化。版权所有© 1999年约翰威利父子有限公司。
Hepatolithiasis and primary sclerosing cholangitis (PSC) are intractable chronic biliary diseases. In hepatolithiasis, bilirubin‐calcium stones are packed in multiple irregularly dilated intrahepatic bile ducts. In PSC, small bilirubin‐calcium stones develop terminally. The progressive periductal fibrosis with dilated and stenotic bile ducts in these two diseases may play a role in their incurability. This immunohistochemical study has investigated the expression of some factors that might be involved in fibrogenesis in hepatolithiasis and PSC. Many mast cells positive for c‐kit were found in the periductal and ductal fibrosis around the intrahepatic large bile ducts and also around the proliferative peribiliary glands. These mast cells also expressed basic fibroblast growth factor and/or tumour necrosis factor‐α, which are known as fibrogenetic factors. It was of interest that the aberrant expression of stem cell factor (SCF), a ligand of c‐kit, was demonstrated on biliary epithelia of the dilated and stenotic bile ducts showing periductal fibrosis and inflammation and also of the proliferated peribiliary glands in hepatolithiasis and PSC, while no such expression was seen in non‐affected bile ducts in hepatolithiasis or in the bile ducts in normal livers. Some of the infiltrating mononuclear cells around the SCF‐expressing bile ducts were also positive for SCF. It seems likely that aberrantly expressed SCF on biliary epithelial cells accumulates and stimulates mast cells via the c‐kit receptor and that these up‐regulated mast cells induce progressive periductal and portal fibrosis by displaying fibrogenetic factors in hepatolithiasis and PSC. Copyright © 1999 John Wiley & Sons, Ltd.
登录
查看更多内容
DOI：
--
发表时间：
1994-02
期刊：
The American journal of pathology
影响因子：
--
作者：
A. Iemura;M. Tsai;A. Ando;B. Wershil;S. Galli
通讯作者：
A. Iemura;M. Tsai;A. Ando;B. Wershil;S. Galli
试剂盒信号转导。
DOI：
10.1016/s0889-8588(05)70294-x
发表时间：
2000
期刊：
Hematology/oncology clinics of North America
影响因子：
--
作者：
Taylor,ML;Metcalfe,DD
通讯作者：
Metcalfe,DD
跨膜 SCF 在肥大细胞-成纤维细胞相互作用中对肥大细胞活化和嗜酸细胞趋化因子产生的新作用。
DOI：
--
发表时间：
1998
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hogaboam,C;Kunkel,SL;Strieter,RM;Taub,DD;Lincoln,P;Standiford,TJ;Lukacs,NW
通讯作者：
Lukacs,NW
大鼠急性期反应的诱导会刺激其肝脏中 α1(I) 前胶原信使核糖核酸的表达。
DOI：
--
发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
Greenwel,P;Iraburu,MJ;Reyes-Romero,M;Meraz-Cruz,N;Casado,E;Solis-Herruzo,JA;Rojkind,M
通讯作者：
Rojkind,M
肺纤维化疾病中的人肥大细胞碱性成纤维细胞生长因子。
DOI：
--
发表时间：
1996
期刊：
The American journal of pathology.
影响因子：
--
作者：
Inoue,Y;KingJr,TE;Tinkle,SS;Dockstader,K;Newman,LS
通讯作者：
Newman,LS