Stimulation stability and selectivity of chronically implanted multicontact nerve cuff electrodes in the human upper extremity.
Stimulation stability and selectivity of chronically implanted multicontact nerve cuff electrodes in the human upper extremity.
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DOI：
10.1109/tnsre.2009.2032603
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Tyler DJ
中科院分区：
文献类型：
--
作者：
Polasek KH;Hoyen HA;Keith MW;Kirsch RF;Tyler DJ
九个螺旋神经套电极被植入两名受试者体内长达三年，没有出现不良的功能影响。这项研究的目的是通过神经套电极观察神经和肌肉对刺激的长期反应。神经传导速度在整个测试期间均保持在临床可接受的范围内。刺激阈值在大约20周后稳定下来。随着时间的推移，激活的可变性与植入功能电刺激系统中使用的基于肌肉的电极没有什么不同。三个电极有多个独立的接触来评估选择性的肌肉恢复。通过单次接触刺激，单个肌肉可以选择性地从每个电极激活，并且使用场转向技术可以增加选择性。三年后的选择性与植入手术期间测量的选择性一致。神经袖电极对人体慢性肌肉激活和多通道功能性电刺激是有效的。
Nine spiral nerve cuff electrodes were implanted in two human subjects for up to three years with no adverse functional effects. The objective of this study was to look at the long term nerve and muscle response to stimulation through nerve cuff electrodes. The nerve conduction velocity remained within the clinically accepted range for the entire testing period. The stimulation thresholds stabilized after approximately 20 weeks. The variability in the activation over time was not different from muscle-based electrodes used in implanted functional electrical stimulation systems. Three electrodes had multiple, independent contacts to evaluate selective recruitment of muscles. A single muscle could be selectively activated from each electrode using single-contact stimulation and the selectivity was increased with the use of field steering techniques. The selectivity after three years was consistent with selectivity measured during the implant surgery. Nerve cuff electrodes are effective for chronic muscle activation and multichannel functional electrical stimulation in humans.