MONOCLONAL-ANTIBODY THAT RECOGNIZES AN OUTER-MEMBRANE ANTIGEN COMMON TO THE PATHOGENIC NEISSERIA SPECIES BUT NOT TO MOST NONPATHOGENIC NEISSERIA SPECIES
MONOCLONAL-ANTIBODY THAT RECOGNIZES AN OUTER-MEMBRANE ANTIGEN COMMON TO THE PATHOGENIC NEISSERIA SPECIES BUT NOT TO MOST NONPATHOGENIC NEISSERIA SPECIES
复制标题
DOI：
10.1128/iai.43.3.994-999.1984
复制
发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
STEWART, PW
中科院分区：
文献类型：
--
作者：
CANNON, JG;BLACK, WJ;STEWART, PW
用淋球菌外膜免疫小鼠，得到一种杂交瘤，产生一种抗体，命名为H.8，它能与所有的淋球菌菌株结合。淋病奈瑟菌和淋病奈瑟菌。对脑膜炎奈瑟氏菌（N. lactamica和N.灰奈瑟氏菌，但很少对其他非致病性奈瑟氏菌属。对用于生产抗体的淋球菌菌株的研究表明，该抗体与表面暴露的、蛋白酶敏感的且可热修饰的外膜抗原结合，该外膜抗原被认为与先前描述的淋球菌外膜蛋白不同。
A hybridoma derived from a mouse immunized with gonococcal outer membranes produced an antibody, designated H.8, that bound to all strains of N. gonorrhoeae and N. meningitidis tested, and to N. lactamica and N. cinerea, but only rarely to other nonpathogenic Neisseria spp. Studies with the gonococcal strain used in production of the antibody showed that the antibody bound to a surface-exposed, protease-sensitive and heat-modifiable outer membrane antigen that is believed to be distinct from previously described gonococcal outer membrane proteins.