ESTIMATION OF ARTERIAL PO2, PCO2, PH, AND LACTATE FROM ARTERIALIZED VENOUS-BLOOD
ESTIMATION OF ARTERIAL PO2, PCO2, PH, AND LACTATE FROM ARTERIALIZED VENOUS-BLOOD
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DOI：
10.1152/jappl.1972.32.1.134
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发表时间：
1972-01-01
影响因子：
3.3
通讯作者：
THOMSON, J
中科院分区：
文献类型：
--
作者：
FORSTER, HV;DEMPSEY, JA;THOMSON, J
福斯特，hv, ja dempsey, j. thomson, e. vidruk和ga dopico。动脉化静脉血中动脉POT、Pco~、pH和乳酸的测定。j:。物理学报，32(1):134-137。1972.-比较动脉血与动脉血静脉血POT、Pco~、pH、乳酸。研究正常受试者和患者在正常休息状态、亚极限和极限工作、CO2呼吸和不同程度的缺氧情况下的情况。手加热（43℃）后，同时从放置在臂动脉和手背浅静脉的导管中采集血液。Pco: !静脉血、乳酸略高于动脉血，pH值低于动脉血。配对样本之间差异的最小方差和所有条件下的一致性允许准确校正静脉到动脉酸碱值。静脉血Poq均明显低于动脉血Poq，低氧血症时差异减小。这种间接方法在任何条件下都不能提供有效的Paos估计。讨论了动脉化方法的应用建议，特别提到：a)它比传统的毛细血管采样技术的优势；b)它在呼吸研究中应用的局限性。留置导管;休息、运动、缺氧、高碳酸血症；静脉动脉化vs毛细血管取样；在静息MAN呼吸室内空气时，动脉化毛细血管的Pco~、pH、Paz和氧饱和度几乎与动脉血相同。耳垂（2、3、6-9、12、13、17- 11）和指尖（3、6、11、17）毛细血管提供这些“动脉”值。在相同的条件下，从手部或前臂浅表静脉取样的动脉化静脉血提供的值与动脉血相似，但并不总是相同（4,5,8,14,15）。这些间接测量被广泛用于确定：1)肺泡通气的充分性，2)生理性死亡空间，3)肺泡-动脉Paz梯度，4)肺静脉-动脉分流，5)CO2再呼吸时的心输出量。然而，通常需要在空气呼吸时休息以外的条件下进行这些测定。因此，本研究的目的是确定在以下情况下从动脉化静脉血中估计这些动脉参数的准确性：1)正常静息条件，2)次最大和最大工作，3)CO，呼吸，4)几种缺氧水平。
FORSTER, HV, JA DEMPSEY, J. THOMSON, E. VIDRUK, AND GA DOPICO. Estimation of arterial POT, Pco~, pH, and lactate from arterialized venous blood. J. Appl. Physiol. 32 (l): 134-137. 1972.-Comparisons were made between arterial and arterialized venous blood POT, Pco~, pH and lactate. Normal subjects and patients were studied during normal resting conditions, submaximal and maximal work, CO2 breathing, and several levels of hypoxia. After heating of the hand (43 C), blood was sampled simultaneously from catheters placed in a brachial artery and a superficial dorsal hand vein. Pco:! and lactate of the venous blood were systematically slightly higher and pH was lower than arterial blood. Minimal variance in the difference between the paired samples and the consistency over all conditions permit accurate correction of venous to arterial acid-base values. The Poq of the venous blood was always significantly lower than arterial, but the difference was reduced with hypoxemia. This indirect method does not provide valid estimation of Paos under any conditions studied. Recommendations for application of the proposed method of arterialization were discussed, with particular reference to: a) its advantages over the more conventional capillary sampling technique and b) the limitations of its application in respiratory studies. indwelling catheter; rest, exercise, hypoxia, and hypercapnia; venous arterialization vs. capillary sampling; limitations of predictabilityIN RESTING MAN breathing room air, the Pco~, pH, Paz, and oxygen saturation of arterialized capillary blood are virtually identical to arterial blood. Both earlobe (2, 3, 6-9, 12, 13, 17-l 9) and fingertip (3, 6, 11, 17) capillary blood provide these “arterial” values. Under the same conditions, arterialized venous blood, sampled from superficial hand or forearm veins, provides values similar to but not always identical to arterial(4, 5, 8, 14, 15). These indirect measurements are widely used to determine: I) the adequacy of alveolar ventilation, 2) physiological dead space, 3) alveolar-toarterial Paz gradients, 4) pulmonary venous to arterial shunts, and 5) cardiac output with CO2 rebreathing. Often, however, there is need for these determinations under conditions other than at rest during air breathing. The purpose of the present study was, then, to determine the accuracy of estimating these arterial parameters from arterialized venous blood during: 1) normal resting conditions, 2) submaximal and maximal work, 3) CO, breathing, and 4) several levels of hypoxia.