Telomerase activity, Ki-67, cyclin D1 and A expression, and apoptosis in solitary fibrous tumors: additional features of a predictable course?
Telomerase activity, Ki-67, cyclin D1 and A expression, and apoptosis in solitary fibrous tumors: additional features of a predictable course?
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孤立性纤维瘤中的端粒酶活性、Ki-67、细胞周期蛋白 D1 和 A 表达以及细胞凋亡：可预测病程的其他特征？
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
V. Ninfo
中科院分区：
文献类型：
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作者：
C. Miracco;M. Santi;L. Pacenti;K. Schürfeld;L. Laurini;L. Pirtoli;P. Luzi;V. Ninfo
孤立性纤维瘤是一种罕见的软组织肿瘤，通常是良性的，可以手术治愈。然而，尽管已经建立了几个恶性肿瘤的临床和病理标准，但它们的行为并不总是可以预测的。端粒酶活性（TA）在许多肿瘤中，包括一些软组织肿瘤，已被证明是一种新的可靠的恶性肿瘤的病理标志物。某些细胞周期蛋白的过表达与较高的恶性程度相关，并可预测临床病程。在这项研究中，我们评估了TA，有丝分裂和凋亡指数（MI，AI），Ki-67，细胞周期蛋白D1和A的表达在5个典型的和两个临床病理不典型的SFT，其中后两个也复发。两例非典型病例TA高，Ki-67标记指数高，cyclin D1和A表达高，无或极少量凋亡。我们建议，TA，Ki-67，细胞周期蛋白的表达，和AI进行评估，在SFTs作为可能的连续性病理标准的行为。
Solitary fibrous tumors (SFTs) are infrequent soft tissue neoplasms which are usually benign and surgically curable. However, their behavior is not always predictable, although several clinical and pathological criteria of malignancy have been established. In many cancers, including some soft tissue tumors, telomerase activity (TA) has been shown to be a new reliable pathological marker of malignancy. Overexpression of some cyclins is associated with higher degrees of malignancy and predictive of the clinical course. In this study, we evaluated TA, mitotic and apoptotic indices (MI, AI), and the expression of Ki-67, cyclins D1 and A in five typical and two clinicopathologically atypical SFTs, the latter two of which had also recurred. High TA was demonstrated in the two atypical cases, which also showed a higher labeling index to Ki-67, as well as higher cyclin D1 and A expression, and either none or very few apoptoses. We suggest that TA, Ki-67, cyclin expression, and AI be evaluated in SFTs as possible adjunctive pathological criteria of behavior.
细胞周期蛋白 D1 的过度表达与四肢软组织肉瘤的不良预后相关。
DOI：
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发表时间：
1998
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research.
影响因子：
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作者：
Kim,SH;Lewis,JJ;Brennan,MF;Woodruff,JM;Dudas,M;Cordon-Cardo,C
通讯作者：
Cordon-Cardo,C
影响因子：
3.7
作者：
SHAY, JW;PEREIRASMITH, OM;WRIGHT, WE
通讯作者：
WRIGHT, WE
正常细胞和肿瘤细胞的相对贡献决定了前列腺癌、结肠癌和肉瘤等原发性癌症中的端粒酶活性和端粒长度。
DOI：
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发表时间：
1997
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research.
影响因子：
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作者：
Engelhardt,M;Albanell,J;Drullinsky,P;Han,W;Guillem,J;Scher,HI;Reuter,V;Moore,MA
通讯作者：
Moore,MA