Nocturnal elevation of intraocular pressure in young adults.
Nocturnal elevation of intraocular pressure in young adults.
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发表时间：
1998-12
影响因子：
4.4
通讯作者：
John H. K. Liu;D. Kripke;R. Hoffman;M. Twa;R. Loving;K. M. Rex;Neeru Gupta;R. Weinreb
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文献类型：
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作者：
John H. K. Liu;D. Kripke;R. Hoffman;M. Twa;R. Loving;K. M. Rex;Neeru Gupta;R. Weinreb
目的区分24小时（昼夜）和姿势对健康年轻人眼内压（IOP）的影响。方法33名志愿者在严格控制的16 h光照和8 h黑暗环境下，在睡眠实验室中进行1 d的睡眠实验。在黑暗时期鼓励睡眠。每2小时使用气压计测量每只眼睛的眼内压。研究人员使用夜视镜在黑暗中进行IOP测量，同时将受试者的光照降至最低。在第一组12名受试者中，在轻度觉醒期间受试者处于坐姿，在黑暗期间受试者处于仰卧位进行测量。在第二组21例受试者中，所有IOP测量均在受试者仰卧位进行。结果两组患者的平均眼压在暗期均显著高于亮-醒期。最低IOP出现在最后一次亮-醒测量中，峰值IOP出现在最后一次暗测量中。第一组IOP的谷峰差为8.2+/-1.4 mm Hg（平均值+/- SEM）。眼压在光暗转换时急剧变化。在第二组中，谷峰IOP差为3.8+/-0.9 mm Hg。眼内压在24小时内逐渐变化。与第一组中的坐位IOP相比，第二组中的仰卧位IOP在轻醒期间显著更高。结论：青年人眼压具有昼夜节律，高峰出现在黑暗后期。夜间IOP升高可以独立于体位变化而出现，但体位从直立到卧位的变化可能导致相对夜间IOP升高。
PURPOSE To distinguish 24-hour (circadian) and postural effects on intraocular pressure (IOP) in healthy young adults. METHODS Thirty-three volunteers were housed in a sleep laboratory for 1 day under a strictly controlled 16-hour light and 8-hour dark environment. Sleep was encouraged in the dark period. Intraocular pressure was measured in each eye every 2 hours using a pneumatonometer. Researchers used night-vision goggles to perform IOP measurements in the dark, while the subject's light exposure was minimized. In the first group of 12 subjects, measurements were taken with subjects in the sitting position during the light-wake period and supine during the dark period. In the second group of 21 subjects, all IOP measurements were taken with the subjects supine. RESULTS Average IOP was significantly higher in the dark period than in the light-wake period in both groups. The lowest IOP occurred in the last light-wake measurement, and the peak IOP occurred in the last dark measurement. The trough-peak difference in IOP was 8.2+/-1.4 mm Hg (mean +/- SEM) in the first group. Intraocular pressure changed sharply at the transitions between light and dark. In the second group, the trough-peak IOP difference was 3.8+/-0.9 mm Hg. Intraocular pressure changed gradually throughout the 24-hour period. In comparison with the sitting IOP in the first group, the supine IOP in the second group was significantly higher during the light-wake period. CONCLUSIONS Circadian rhythms of IOP were shown in young adults, with the peaks occurring in the late dark period. A nocturnal IOP elevation can appear independent of body position change, but change of posture from upright to recumbent may contribute to the relative nocturnal IOP elevation.