OBSERVATIONS ON THE NATURE OF SUBEPENDYMOMA: AN ELECTRON MICROSCOPIC STUDY
OBSERVATIONS ON THE NATURE OF SUBEPENDYMOMA: AN ELECTRON MICROSCOPIC STUDY
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对室管膜下瘤性质的观察：电子显微镜研究
DOI：
10.1111/j.1365-2990.1984.tb00341.x
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发表时间：
1984
影响因子：
5
通讯作者：
T. Moss
中科院分区：
文献类型：
--
作者：
T. Moss
本文对四例具有典型光镜特征的症状性第四脑室室管膜下瘤的手术活检材料进行了电镜研究。每个病例的超微结构外观相似，核周围的小群肿瘤细胞被含有胶质丝的细胞突网广泛分开。缺乏特化特征的大细胞在所有病例中都很突出，与成年动物室管膜下层的室管膜胶质前体细胞相似。其他细胞表现为星形细胞或发育不良的室管膜特征，两者之间的过渡形式很常见，表明肿瘤为单一细胞类型。微绒毛袋存在，但它们与室管膜型微莲座不同，缺乏紧密的连接复合物。与低级别星形细胞瘤不同，细胞外间隙小，肿瘤细胞突起与血管无密切联系。这些观察结果表明，室管膜下瘤可能被视为与其他第四脑室肿瘤不同的实体，可能起源于通常存在于成人室管膜下层的室管膜胶质细胞。
Surgical biopsy material from four cases of symptomatic fourth ventricle subependymoma, all with typical light microscopic features, was studied by electron microscopy. The ultrastructural appearance of each case was similar, with small groups of tumour cell perikarya widely separated by a meshwork of cell processes containing glial filaments. Large cells lacking specialised features were prominent in all cases and showed similarities with ependymoglial precursor cells described in the adult subependymal layer of animals. Other cells showed either astrocytic or poorly developed ependymal features, and transitional forms between these two appearances were common, suggesting the tumour to be of a single cell type. Pockets of microvilli were present, but they differed from ependymal‐type micro‐rosettes in lacking tight junctional complexes. Unlike low grade astrocytomas, the extracellular space was small and there was no close association of tumour cell processes with blood vessels. These observations suggest that the subependymoma may be regarded as a separate entity from other fourth ventricle neoplasms and possibly takes origin from ependymoglial cells normally present in the adult subependymal layer.