The hitchhiking effect of an autosomal meiotic drive gene
The hitchhiking effect of an autosomal meiotic drive gene
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DOI：
10.1534/genetics.105.052977
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发表时间：
2006-07-01
期刊：
影响因子：
3.3
通讯作者：
Hospital, Frederic
中科院分区：
文献类型：
--
作者：
Chevin, Luis-Miguel;Hospital, Frederic
传递率畸变是指杂合个体配子中等位基因的1：1分离偏离。所谓的驱动等位基因被强烈选择，而不管它对携带个体的适应性的影响。由于遗传搭便车效应，它可能对中性多态性产生重要影响。我们研究了这种搭便车效应的情况下，真正的减数分裂驱动器中的常染色体，并表明，它是更依赖于重组率比在经典的情况下，积极选择在生物体水平的基因。
Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genetic hitchhiking effect. We study this hitchhiking effect in the case of true meiotic drive in autosomes and show that it is more dependent on the recombination rate than in the classical case of a gene positively selected at the organism level.