Vitamin D and cancer: a review of molecular mechanisms.
Vitamin D and cancer: a review of molecular mechanisms.
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DOI：
10.1042/bj20110744
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
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作者：
Fleet JC;DeSmet M;Johnson R;Li Y
基于人群的维生素D水平低和癌症风险增加之间的联系可能是不一致的，但现在已经被普遍接受。这些关系将低水平的血清25羟基维生素D与癌症联系在一起，而基于细胞的研究表明，代谢物1，25二羟基维生素D是一种生物活性代谢物，通过维生素D受体调节基因转录。在这里，我们回顾了与可能解释维生素D对癌症预防或治疗的有益影响的分子事件相关的文献。这一数据表明，虽然维生素D诱导肿瘤细胞或其非肿瘤前体细胞的生长停滞和凋亡是合理的机制，但其他化学保护机制也值得考虑。这些替代机制包括增强DNA修复、抗氧化保护和免疫调节。此外，其他细胞靶点，如基质细胞、内皮细胞和免疫系统的细胞，可能受到1，25二羟基维生素D的调节，有助于维生素D介导的癌症预防。
The population-based association between low vitamin D status and increased cancer risk can be inconsistent but is now generally accepted. These relationships link low serum 25 hydroxyvitamin D levels to cancer while cell-based studies show that the metabolite 1,25 dihydroxyvitamin D is the biologically active metabolite that works through vitamin D receptor to regulate gene transcription. Here we review the literature relevant to the molecular events that may account for the beneficial impact of vitamin D on cancer prevention or treatment. This data shows that while vitamin D-induced growth arrest and apoptosis of tumor cells or their non-neoplastic progenitors are plausible mechanisms, other chemoprotective mechanisms are also worthy of consideration. These alternative mechanisms include enhancing DNA repair, antioxidant protection, and immunomodulation. In addition, other cell targets such as the stromal cells, endothelial cells, and cells of the immune system may be regulated by 1,25 dihydroxyvitamin D and contribute to vitamin D mediated cancer prevention.