Cyclophilin involvement in the replication of hepatitis C virus and other viruses.
Cyclophilin involvement in the replication of hepatitis C virus and other viruses.
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DOI：
10.1515/hsz-2012-0151
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发表时间：
2012-07
影响因子：
3.7
通讯作者：
Gallay P
中科院分区：
文献类型：
--
作者：
Baugh J;Gallay P
近几个月来，有大量有希望的临床数据表明，一种更有效的治疗丙型肝炎病毒(HCV)感染的治疗方案即将到来，而且有可能治愈。引领这一努力的是直接作用抗病毒药物(DAA)，目前由靶向丙型肝炎病毒蛋白酶NS3、病毒聚合酶NS5B和非结构蛋白NS5A的抑制剂组成。与利巴韦林和聚乙二醇化干扰素α的传统护理标准相结合，这些化合物已被证明对治疗幼稚的患者以及先前的无应答患者具有巨大的疗效。然而，通过以病毒成分为目标，选择具有突破性和抗药性的病毒株的可能性仍然令人担忧。宿主靶向抗病毒药物(HTA)是一类独特的抗丙型肝炎病毒化合物，正在成为抗击这种疾病的一套补充工具。亲环素(Cyp)抑制剂就是这类药物中的一种。与DAA不同，CyP抑制剂针对宿主蛋白CypA，在临床试验中也显示出显著的抗病毒效率，而不会产生病毒逃逸突变。本文综述了亲环素及其与丙型肝炎病毒生命周期和其他病毒的关系。
In recent months there has been a wealth of promising clinical data suggesting that a more effective treatment regimen, and potentially a cure, for hepatitis C virus (HCV) infection is close at hand. Leading this push are direct acting antivirals (DAAs), currently comprised of inhibitors that target the HCV protease NS3, viral polymerase NS5B and the nonstructural protein NS5A. In combination with one another, along with the traditional standard of care ribavirin and PEGylated-IFNα, these compounds have proven to afford tremendous efficacy to treatment-naïve patients, as well as to prior non-responders. Nevertheless, by targeting viral components the possibility of selecting for breakthrough and treatment-resistant virus strains remains a concern. Host-targeting antivirals (HTAs) are a distinct class of anti-HCV compounds that is emerging as a complementary set of tools to combat the disease. Cyclophilin (Cyp) inhibitors are one such group in this category. In contrast to DAAs, Cyp inhibitors target a host protein, CypA, and have also demonstrated remarkable antiviral efficiency in clinical trials, without the generation of viral escape mutants. This review serves to summarize the current literature on cyclophilins and their relationship to the HCV viral life cycle, as well as other viruses.
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影响因子：
4.8
作者：
Anderson LJ;Lin K;Compton T;Wiedmann B
通讯作者：
Wiedmann B
影响因子：
3.7
作者：
Coelmont L;Hanoulle X;Chatterji U;Berger C;Snoeck J;Bobardt M;Lim P;Vliegen I;Paeshuyse J;Vuagniaux G;Vandamme AM;Bartenschlager R;Gallay P;Lippens G;Neyts J
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Neyts J
影响因子：
13.5
作者：
Ciesek, Sandra;Steinmann, Eike;Pietschmann, Thomas
通讯作者：
Pietschmann, Thomas
影响因子：
3.8
作者：
de Wilde, Adriaan H.;Zevenhoven-Dobbe, Jessika C.;van Hemert, Martijn J.
通讯作者：
van Hemert, Martijn J.
影响因子：
11.4
作者：
Braaten, D;Luban, J
通讯作者：
Luban, J