Recollection-Related Hippocampal Activity During Continuous Recognition: A High-Resolution fMRI Study
Recollection-Related Hippocampal Activity During Continuous Recognition: A High-Resolution fMRI Study
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DOI：
10.1002/hipo.20781
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发表时间：
2011-06-01
期刊：
影响因子：
3.5
通讯作者：
Rugg, Michael D.
中科院分区：
文献类型：
--
作者：
Suzuki, Maki;Johnson, Jeffrey D.;Rugg, Michael D.
我们使用高分辨率功能磁共振成像来研究连续识别过程中的成功回忆是否与海马活动的相对增强相关，这与采用单独研究和测试阶段的实验结果一致。当被扫描时，受试者区分新的和重复的图片。每隔10到30个项目重复一次，每张图片周围都有一个灰色、蓝色或橙子的框架。当一个项目重复时，它的框架颜色决定了正确的反应。被灰色框包围的重复项目总是需要一个“旧”的判断。由蓝色或橙子框架包围的重复项目需要不同的响应，这取决于它是以与第一次呈现相同的（目标）还是不同的（非目标）颜色表示的。与先前连续再认实验的结果一致，在双侧海马中发现了鲁棒的新>旧效应。此外，跨学科的相关性分析确定了一个集群的体素在右侧海马体的回忆相关的活动（操作之间的对比正确与不正确的判断非目标）与回忆性能呈正相关。因此，连续识别过程中的成功回忆与海马活动的相对增强有关。(C)2010 Wiley-Liss，Inc.
We used high-resolution functional magnetic resonance imaging to investigate whether successful recollection during continuous recognition is associated with relative enhancement of hippocampal activity, consistent with prior findings from experiments employing separate study and test phases. While being scanned, subjects discriminated between new and repeated pictures. Each picture, which was repeated once after an interval of between 10 and 30 items, was surrounded by a frame that was colored gray, blue, or orange. When an item repeated, its frame color determined the correct response. Repeated items surrounded by a gray frame always required an "old" judgment. A repeated item surrounded by a blue or an orange frame required a different response depending whether it was represented in the same (Target) or a different (Nontarget) color from the first presentation. Consistent with the results from previous continuous recognition experiments, robust new > old effects were found in bilateral hippocampus. In addition, an across-subjects correlational analysis identified a cluster of voxels in right hippocampus where recollection-related activity (operationalized by the contrast between correctly vs. incorrectly judged Non-targets) was positively correlated with recollection performance. Thus, successful recollection during continuous recognition is associated with a relative enhancement of hippocampal activity. (C) 2010 Wiley-Liss, Inc.