Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice
Behaviour in the elevated plus-maze predicts coping after subchronic mild stress in mice
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DOI：
10.1016/j.physbeh.2004.01.013
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发表时间：
2004-05-01
影响因子：
2.9
通讯作者：
Belzung, C
中科院分区：
文献类型：
--
作者：
Ducottet, C;Belzung, C
本研究旨在探讨亚慢性不可预测性轻度应激过程中小鼠的应对方式及其与初始情绪反应的关系。两个近交系小鼠，BALB/c ByJ和C57 BL/6 J，已知表现出不同的情绪，已被使用。它们首先在高架十字迷宫和自由探索范式中被观察到，每一个都提供了高情绪和低情绪小鼠群体的分离。然后，每种品系的一半小鼠面临2周的亚慢性不可预测的轻度应激，并测试它们在不同行为情况下的反应（食用可口食物、身体状态、梳理行为和对冲突情况的反应）。还在明/暗程序中测试小鼠以评估亚慢性应激对情绪反应的影响。首先，发现高架十字迷宫中的初始情绪反应与应对压力的行为应对方式之间的关系，高情绪小鼠（即，BALB小鼠）表现出抑制的行为和较少情绪化的小鼠（即，BL/6小鼠）表现出很少的行为变化。此外，与非应激小鼠相比，应激小鼠的情绪反应增加。(C)2004年爱思唯尔公司All rights reserved.
This study was aimed at investigating the coping style of mice subjected to a subchronic unpredictable mild stress procedure and its relationship to initial emotional reactivity. Two inbred strains of mice, the BALB/c ByJ and the C57BL/6 J, known to exhibit distinct emotionality, have been used. They were first observed in the elevated plus-maze and the free exploratory paradigm, each provides a separation of the population in high and low emotional mice. Half of the mice of each strain were then confronted to a 2-week subchronic unpredictable mild stress and tested for their responses in different behavioural situations (consumption of a palatable food, physical state, grooming behaviours and reactivity to a conflict situation). Mice were also tested in the light/dark procedure to assess the effect of the subchronic stress on emotional reactivity. First, a relationship between initial emotional reactivity in the elevated plus-maze and behavioural coping style in response to stress was found, high emotional mice (i.e., BALB mice) displaying inhibited behaviours and less emotional mice (i.e., BL/6 mice) exhibiting few behavioural changes. Furthermore, emotional reactivity was increased in stressed mice compared with nonstressed ones. (C) 2004 Elsevier Inc. All rights reserved.