Inflammation in Benign Prostatic Hyperplasia: A 282 Patients' Immunohistochemical Analysis
Inflammation in Benign Prostatic Hyperplasia: A 282 Patients' Immunohistochemical Analysis
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DOI：
10.1002/pros.21027
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发表时间：
2009-12-01
期刊：
影响因子：
2.8
通讯作者：
de la Taille, Alexandre
中科院分区：
文献类型：
--
作者：
Robert, Gregoire;Descazeaud, Aurelien;de la Taille, Alexandre
引言和目标。前列腺炎症可能是前列腺肥大和良性前列腺增生症(BPH)进展的关键因素。我们的目的是确定BPH组织中炎性细胞的特征，并将炎症和临床数据联系起来。在三个临床结果组织芯片(TMA)上描述了炎症情况，包括282名因复杂和/或有症状的BPH而接受手术治疗的患者。结合6项细胞学指标和5项免疫组织化学标志物(IHC)进行炎症评分。细胞学参数为淋巴细胞、巨噬细胞和多核白细胞渗入，以及三种腺体方面的改变：腺体萎缩、腺体破坏和组织纤维化。结果：大多数患者有炎症细胞渗入前列腺组织：81%为T淋巴细胞标志物(CD3)，52%为B淋巴细胞标志物(CD20)，82%为巨噬细胞标志物(CD163)。高度前列腺炎患者的IPSS评分(21cm3比12cm3；P=0.02)和前列腺体积(77cm3比62cm3；P=0.002)显著高于对照组。炎症在BPH发展中的作用被组织学炎症、IPSS和前列腺体积之间的强烈相关性所强调。慢性炎症过程导致的前列腺肥大可能逐渐导致BPH的进展。因此，炎症是BPH的治疗靶点。前列腺69：1774-1780,2009。(C)2009年Wiley-Liss，Inc.
INTRODUCTION AND OBJECTIVES. Prostatic inflammation could be a key component in prostate enlargement and benign prostatic hyperplasia (BPH) progression. Our aim was to characterize inflammatory cells infiltrate within BPH tissue and to correlate inflammation and clinical data.MATERIAL AND METHODS. Inflammation was profiled on three clinical outcome tissue microarrays (TMAs), including 282 patients treated by surgery for a complicated and/or symptomatic BPH. Inflammation score was defined by combining six cytological parameters and five markers on immunohistochemistry (IHC). Cytological parameters were lymphocytes, macrophages, and polynuclears leukocytes infiltrates, and three glandular aspect modifications: glandular atrophy, glandular destruction, and tissue fibrosis. IHC markers were CD3, CD4, and CD8 decorating T-lymphocytes, CD20 decorating B-lymphocytes, and CD163 decorating macrophages.RESULTS. The majority of patients had inflammatory cells infiltrating BPH tissues: 81% had T-lymphocytes markers (CD3), 52% had B-lymphocytes markers (CD20), and 82% had macrophages markers (CD163). IPSS score (21 vs. 12; P = 0.02) and prostate volume (77 cm 3 vs. 62 cm 3; P = 0.002) were significantly higher in patients with high-grade prostatic inflammation.CONCLUSION. We characterized inflammatory cells infiltrate in a large cohort of surgically treated BPH specimens. The role of inflammation in BPH development was highlighted by the strong correlation between histological inflammation, IPSS, and prostate volume. Prostate enlargement due to chronic inflammatory process may progressively conduce to BPH progression. Therefore, inflammation is a therapeutic target for BPH. Prostate 69: 1774-1780, 2009. (C) 2009 Wiley-Liss, Inc.