Estrogen metabolism and breast cancer.
Estrogen metabolism and breast cancer.
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雌激素代谢和乳腺癌。
DOI：
10.1016/j.canlet.2014.04.018
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发表时间：
2015-01-28
期刊：
影响因子：
9.7
通讯作者：
Kurzer MS
中科院分区：
文献类型：
--
作者：
Samavat H;Kurzer MS
目前有越来越多的证据表明，内源性雌激素在乳腺癌的发展中起着关键作用。对绝经前和绝经后妇女的雌激素及其代谢物进行了研究，在绝经后的人群中显示出更一致的结果，部分原因是在月经周期中激素变化很大，而对绝经前妇女的研究要少得多。在这篇综述中，我们详细描述了雌激素代谢和相关的遗传变异，并对目前关于雌激素及其代谢物在乳腺癌风险中的作用的文献进行了综述。
There is currently accumulating evidence that endogenous estrogens play a critical role in the development of breast cancer. Estrogens and their metabolites have been studied in both pre- and postmenopausal women with more consistent results shown in the latter population, in part because of large hormonal variations during the menstrual cycle and far fewer studies having been performed in premenopausal women. In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.