Copper‐Catalyzed Isomerization and Cyclization of E/Z‐o‐Haloaryl N‐Sulfonylhydrazones: Convenient Access to 1H‐Indazoles
Copper‐Catalyzed Isomerization and Cyclization of E/Z‐o‐Haloaryl N‐Sulfonylhydrazones: Convenient Access to 1H‐Indazoles
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DOI：
10.1002/cctc.201601243
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发表时间：
2017-03
期刊：
影响因子：
4.5
通讯作者：
Xue-Qing Zhu;Shuai Mao;Dong‐Dong Guo;Bin Li;Shi‐Huan Guo;Ya-Ru Gao;Yong-Qiang Wang
中科院分区：
文献类型：
--
作者：
Xue-Qing Zhu;Shuai Mao;Dong‐Dong Guo;Bin Li;Shi‐Huan Guo;Ya-Ru Gao;Yong-Qiang Wang
腙类化合物中C=N双键的异构化反应因其在广泛的化学转化中的潜在应用而引起人们的广泛关注。通常，这种异构化可以通过光化学或热的方式实现。提出了一种新的异构化方法，即铜催化的C=N双键异构化腙，随后是有效的分子内C-N偶联反应，提供了一种前所未有的催化方法，用于从容易获得的Z/E混合物的邻卤芳基N-磺酰腙合成1H-吲唑。
The isomerization of the C=N double bond in hydrazones has drawn considerable attention because of its potential for application in a broad range of chemical transformations. Generally, this isomerization can be realized either photochemically or thermally. A new isomerization approach is presented, namely a copper‐catalyzed C=N double bond isomerization of hydrazones, which is followed by an efficient intramolecular C−N coupling reaction, providing an unprecedented catalytic approach for the synthesis of 1H‐indazoles from readily accessible Z/E mixture of o‐haloaryl N‐sulfonylhydrazones.